用于骨修复中可降解生物陶瓷的制备与性能优化

赵越; 赵一楠; 许燕; 陈宇彤; 印治涛; 晁坚; 周建平

doi:10.7652/xjtuxb202506009

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用于骨修复中可降解生物陶瓷的制备与性能优化

专题　材料性能优化 | 更新时间：2025-08-26

- 用于骨修复中可降解生物陶瓷的制备与性能优化
- Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair
- 西安交通大学学报 2025年59卷第6期页码：82-92
- 作者机构：
  
  1.新疆大学机械工程学院， 830047，乌鲁木齐
  2.华中科技大学材料科与技术系， 430074，武汉
- 作者简介：
  
  赵越（2000—），女，硕士生；
  许燕，女，教授，博士生导师。
- 基金信息：
  
  新疆维吾尔自治区自然科学基金资助项目(2022D01C34);国家自然科学基金资助项目(52365053)
- DOI：10.7652/xjtuxb202506009
  中图分类号： TH114
- 收稿：2024-11-18，
  
  网络首发：2025-01-22，
  
  纸质出版：2025-06-10
- 稿件说明：
移动端阅览
赵越, 赵一楠, 许燕, 等. 用于骨修复中可降解生物陶瓷的制备与性能优化[J]. 西安交通大学学报, 2025,59(6):82-92.

ZHAO Yue, ZHAO Yinan, XU Yan, et al. Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair[J]. Journal of Xi’an Jiaotong University, 2025, 59(6): 82-92.
赵越, 赵一楠, 许燕, 等. 用于骨修复中可降解生物陶瓷的制备与性能优化[J]. 西安交通大学学报, 2025,59(6):82-92. DOI： 10.7652/xjtuxb202506009.

ZHAO Yue, ZHAO Yinan, XU Yan, et al. Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair[J]. Journal of Xi’an Jiaotong University, 2025, 59(6): 82-92. DOI： 10.7652/xjtuxb202506009.

摘要

针对骨修复应用中硅酸钙存在机械强度不足的问题，通过化学沉淀法，制备了一种掺镁硅酸钙陶瓷材料，并构建了兼具良好机械强度和生物相容性的骨修复支架。首先，向硅酸钙粉体中引入不同质量分数的镁粉末颗粒，并改变镁与硅酸钙粉体的掺杂比例，通过球磨、脱脂烧结等工艺制备掺镁硅酸钙陶瓷材料；然后，采用3D打印数字光处理技术(DLP)，打印内、外直径分别为2.8 mm和5 mm，高度为6 mm的空心圆柱，构建用于骨修复的骨支架；最后，采用力学实验、CCK-8细胞增殖检测和碱性磷酸酶检测(ALP)，探究镁掺杂量对可降解生物陶瓷抗压强度和生物相容性的影响规律。实验结果表明：所构建掺镁硅酸钙支架的弹性模量为94～110 MPa，是硅酸钙支架弹性模量(33 MPa)的2.85～3.33倍；掺镁质量分数分别为5%和10%的掺镁硅酸钙支架细胞存活率为94%～97%，具有良好的生物相容性；掺镁质量分数分别为15%和20%的掺镁硅酸钙支架细胞存活率均低于70%，不利于细胞增殖；当掺镁质量分数为10%、烧结温度为1 000 ℃时，掺镁硅酸钙支架兼具最佳的力学性能和生物相容性。

Abstract

In response to the insufficient mechanical strength of calcium silicate in bone repair applications

a magnesium-doped calcium silicate ceramic material was prepared using a chemical precipitation method

and a bone repair scaffold with both excellent mechanical strength and biocompatibility was constructed. First

magnesium powder particles with different mass fractions were introduced into the calcium silicate powder

and the doping ratio of magnesium to calcium silicate powder was adjusted. Magnesium-doped calcium silicate ceramic materials were prepared by ball milling and de-binding sintering and other processes. Then

a 3D printing digital light processing (DLP) technique was used to print hollow cylinders with inner and outer diameters of 2.8 mm and 5 mm respectively

and a height of 6 mm

to construct bone scaffolds for bone repair. Finally

mechanical tests

CCK-8 cell proliferation assays

and alkaline phosphatase (ALP) tests were conducted to explore the effects of magnesium doping on the compressive strength and biocompatibility of biodegradable bioceramics. The experimental results showed that the elastic modulus of the magnesium-doped calcium silicate scaffold ranged from 94 MPa to 110 MPa

which is 2.85 to 3.33 times that of the calcium silicate scaffold (33 MPa). The cell viability of magnesium-doped calcium silicate scaffolds with mass fractions of 5% and 10% ranged from 94% to 97%

indicating good biocompatibility. In contrast

scaffolds with magnesium mass fractions of 15% and 20% exhibited cell viability below 70%

which is unfavorable for cell proliferation. With a magnesium doping level of 10% and a sintering temperature of 1 000 ℃

the magnesium-doped calcium silicate scaffold achieved the optimal combination of mechanical properties and biocompatibility.

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references

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