微纳材料在氢分子医疗中的应用

李东; 林展乐; 冯璟; 师进文; 孙成珍; 张浩; 余泽佳; 陈斌; 王国祥; 周致富; 姚亮; 郑玉萍; 王慧渊; 高宁

doi:10.7652/xjtuxb202505004

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微纳材料在氢分子医疗中的应用

专题　医工交叉与人机交互 | 更新时间：2025-08-26

- 微纳材料在氢分子医疗中的应用
- Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine
- 西安交通大学学报 2025年59卷第5期页码：30-43
- 作者机构：
  
  1.西安交通大学动力工程多相流国家重点实验室， 710049，西安
  2.阿克伦大学机械工程系， 44325，美国阿克伦
  3.西安交通大学第二附属医院， 710004，西安
  4.西安交通大学第一附属医院， 710061，西安
- 作者简介：
  
  李东（1982—），男，副教授；
  陈斌（通信作者），男，教授，博士生导师。
- 基金信息：
  
  国家自然科学基金资助项目(52276084);陕西省重点研发计划资助项目(2024QY2-GJHX-41);西安市引进海外高层次人才项目(24HWYZ0049)
- DOI：10.7652/xjtuxb202505004
  中图分类号： R318
- 收稿：2024-10-28，
  
  网络首发：2025-01-13，
  
  纸质出版：2025-05-10
- 稿件说明：
移动端阅览
李东, 林展乐, 冯璟, 等. 微纳材料在氢分子医疗中的应用[J]. 西安交通大学学报, 2025,59(5):30-43.

LI Dong, LIN Zhanle, FENG Jing, et al. Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine[J]. Journal of Xi’an Jiaotong University, 2025, 59(5): 30-43.
李东, 林展乐, 冯璟, 等. 微纳材料在氢分子医疗中的应用[J]. 西安交通大学学报, 2025,59(5):30-43. DOI： 10.7652/xjtuxb202505004.

LI Dong, LIN Zhanle, FENG Jing, et al. Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine[J]. Journal of Xi’an Jiaotong University, 2025, 59(5): 30-43. DOI： 10.7652/xjtuxb202505004.

摘要

自2007年首次发现氢分子具有选择性抗氧化特性以来，氢分子迅速成为现代医学研究的热点，多项研究已证实其在多种动物模型和人类疾病中发挥着积极作用。针对传统氢分子给药（如吸入氢气、饮用富氢水和注射氢盐水等）存在的利用率低、释放难以控制和靶向性不足等问题，微纳材料给出了新的解决方案。从微纳材料的释氢原理出发，综述了吸附载氢与原位释氢两种主要策略，以及它们在协同治疗中的前沿应用。吸附载氢依靠物理或化学吸附储存氢气，通过温度、压力等外部调控实现释放；原位释氢则利用化学反应、光热催化或生物手段在特定病理环境中生成氢气，可通过内源响应或外源调控达到更高的靶向性和可控性。以微纳材料为媒介，结合氢分子的抗炎、抗肿瘤等功能，氢分子还可通过与化疗药物、光热疗法及光动力疗法的协同作用，显著增强对肿瘤疾病的治疗效果。同时，还总结了当前面临的生物安全性、靶向性及规模化生产等挑战，并提出未来需通过设计智能响应材料及氢分子多模式协同治疗相结合，进一步提高治疗效果与精准性，为后续基于微纳材料的氢分子医学提供了指导。

Abstract

Since the selective antioxidant properties of hydrogen molecules were first discovered in 2007

hydrogen molecules has rapidly become a research focus in modern medicine. In numerous studies

its positive effects in various animal models and human diseases have been demonstrated. In response to the issues of low utilization

difficulty in controlling release

and insufficient targeting associated with traditional hydrogen molecule delivery methods (such as inhaling hydrogen gas

drinking hydrogen-rich water

and injecting hydrogen saline)

micro-nano materials offer new solutions. Starting from the hydrogen release mechanism of micro-nano materials

two main strategies are discussed in this review: hydrogen adsorption and in situ hydrogen release

as well as their cutting-edge applications in synergistic therapies. Hydrogen adsorption relies on physical or chemical adsorption for hydrogen storage

with release controlled by external stimuli such as temperature and pressure. In contrast

in situ hydrogen release utilizes chemical reactions

photothermal catalysis

or biological mechanisms to generate hydrogen in specific pathological environments

achieving higher targeting and controllability through endogenous responses or exogenous regulation. Utilizing micro-nano materials as a medium

and combining the anti-inflammatory and anti-tumor functions of hydrogen molecules

hydrogen molecules can significantly enhance the therapeutic effect on tumor diseases through synergistic interactions with chemotherapy drugs

photothermal therapy

and photodynamic therapy. In this review

current challenges

including issues of biosafety

targeting

and scalable production are also summarized

and future directions such as the design of smart responsive materials combined with multimodal synergistic therapy using hydrogen molecules are proposed

to further improve therapeutic precision and efficacy. This provides guidance for subsequent advancements in hydrogen molecular medicine based on micro-nano materials.

关键词

Keywords

references

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