3D打印三周期极小曲面多孔钽仿生骨支架结构设计及力学性能研究

时艺; 乌日开西·艾依提; 张宇涛

doi:10.7652/xjtuxb202412019

您当前的位置：

首页 >

文章列表页 >

3D打印三周期极小曲面多孔钽仿生骨支架结构设计及力学性能研究

—————————————————————— | 更新时间：2025-07-28

- 3D打印三周期极小曲面多孔钽仿生骨支架结构设计及力学性能研究
- Structural Design and Mechanical Properties of 3D Printed Triply Periodic Minimal Surfaces Porous Tantalum Bionic Bone Scaffold
- 西安交通大学学报 2024年58卷第12期页码：197-207
- 作者机构：
  
  1. 新疆大学智能制造现代产业学院(机械工程学院),乌鲁木齐,830017
  2. 新疆工程学院机电工程学院,乌鲁木齐,830023
- 作者简介：
  
  : 2024-04-14。作者简介: 时艺(1999—),女,硕士生
  乌日开西·艾依提(通信作者),男,教授,博士生导师。基金项目: 国家自然科学基金资助项目(52065063)
- 基金信息：
  
  : 2024-04-14。作者简介: 时艺(1999—),女,硕士生;乌日开西·艾依提(通信作者),男,教授,博士生导师。基金项目: 国家自然科学基金资助项目(52065063);新疆维吾尔自治区自然科学基金资助项目(2023D01A86)。
- DOI：10.7652/xjtuxb202412019
  中图分类号： G665
- 网络首发：2024-12-10，
  
  纸质出版：2024
- 稿件说明：
移动端阅览
时艺, 乌日开西·艾依提, 张宇涛. 3D打印三周期极小曲面多孔钽仿生骨支架结构设计及力学性能研究[J]. 西安交通大学学报, 2024,58(12):197-207.

SHI Yi, Wurikaixi AIYITI, ZHANG Yutao. Structural Design and Mechanical Properties of 3D Printed Triply Periodic Minimal Surfaces Porous Tantalum Bionic Bone Scaffold[J]. 2024, 58(12): 197-207.
时艺, 乌日开西·艾依提, 张宇涛. 3D打印三周期极小曲面多孔钽仿生骨支架结构设计及力学性能研究[J]. 西安交通大学学报, 2024,58(12):197-207. DOI： 10.7652/xjtuxb202412019.

SHI Yi, Wurikaixi AIYITI, ZHANG Yutao. Structural Design and Mechanical Properties of 3D Printed Triply Periodic Minimal Surfaces Porous Tantalum Bionic Bone Scaffold[J]. 2024, 58(12): 197-207. DOI： 10.7652/xjtuxb202412019.

摘要

为了实现植入物与人体骨在生物力学和细胞相容性方面的匹配

综合评价了钽点阵结构的力学性能和渗透性能

以寻求可应用于钽多孔骨支架的最佳点阵结构。基于三周期极小曲面的不同建模方法

设计了6种类型的单元体结构

通过选区激光熔化工艺制备了相关钽点阵结构试样。通过准静态压缩试验获得点阵结构的力学性能

并记录破坏过程; 基于有限元软件Abaqus建立相对应的压缩模型

获取压缩过程中应力应变的变化; 利用COMSOL软件对点阵结构的渗透性能进行模拟分析。结果表明:片状结构的弹性模量、屈服强度和能量吸收均高于杆状结构

渗透率则低于杆状结构; G型和F-KS型杆状结构在50%应变下出现了脆性断裂的裂口; 6种钽点阵结构的弹性模量为3.8～6.1 GPa

屈服强度为47～107 MPa

介于皮质骨和松质骨的范围内; 6种结构的渗透率为6.5×10

-10

～3.97×10

-9

均在骨小梁的渗透率范围内。研究结果表明

所设计的钽点阵结构适用于骨支架

综合性能最好的是G型片状结构。

Abstract

In order to ensure compatibility between implants and human bone in terms of biomechanics and cell integration

a comprehensive evaluation of the mechanical and permeability properties of tantalum lattice structures is conducted to identify the optimal lattice structure for porous tantalum bone scaffolds. Six types of unit cell structures are designed based on various modeling approaches for triply periodic minimal surfaces. Samples of relevant tantalum lattice structures are pr

epared using selective laser melting technology. The mechanical characteristics of these lattice structures are determined through quasi-static compression tests

and the failure processes are documented. Utilizing the finite element software Abaqus

a compression model is developed to analyze stress-strain variations during compression. The permeability performance of the lattice structures is simulated and assessed using the COMSOL software. The findings reveal that the lamellar structure exhibits higher elastic modulus

yield strength

and energy absorption compared to the rod structure

while its permeability is lower. Particularly

the G-type and F-KS type rod structures demonstrate brittle fractures at a 50% strain. The elastic modulus of the six tantalum lattice structures ranges from 3.8 to 6.1 GPa

and the yield strength ranges from 47 to 107 MPa

aligning within the spectrum of cortical and cancellous bone. The permeability of the six structures ranges from 6.5×10

-10

to 3.97×10

-9

falling within the typical permeability range of trabeculae bone. These results affirm the suitability of the designed tantalum lattice structures for bone scaffolds

with the G-type lamellar structure displaying the best overall performance.

关键词

Keywords

references

LASANIANOS N G, KANAKARIS N K, GIANNOUDIS P V. Current management of long bone large segmental defects [J]. Orthopaedics and Trauma, 2010, 24(2): 149-163.

DENG Fuyuan, LIU Linlin, LI Zhong, et al. 3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth [J]. Journal of Biological Engineering, 2021, 15(1): 4.

LI Jiaojiao, EBIED M, XU J, et al. Current approaches to bone tissue engineering: the interface between biology and engineering [J]. Advanced Healthcare Materials, 2018, 7(6): 1701061.

JANG T S, JUNG H D, KIM S, et al. Multiscale porous titanium surfaces via a two-step etching process for improved mechanical and biological performance [J]. Biomedical Materials, 2017, 12(2): 025008.

JI Tao, YANG Yi, TANG Xiaodong, et al. 3D-Printed modular hemipelvic endoprosthetic reconstruction following periacetabular tumor resection: early results of 80 consecutive cases [J]. The Journal of Bone and Joint Surgery, 2020, 102(17): 1530-1541.

GRUBER M S, JESENKO M, BURGHUBER J, et al. Functional and radiological outcomes after treatment with custom-made acetabular components in patients with Paprosky type 3 acetabular defects: short-term results [J]. BMC Musculoskeletal Disorders, 2020, 21(1): 835.

陈凯, 宋会平. 多孔钽-细胞-骨界面作用的研究进展 [J]. 中国骨与关节杂志, 2021, 10(6): 473-477.

CHEN Kai, SONGHuiping. Research progress of porous tantalum on bone cells and interface [J]. Chinese Journal of Bone and Joint, 2021, 10(6): 473-477.

石晓岫, 吴先哲, 马幸双, 等. 钽材的医学应用及生物相容性机制 [J]. 功能材料, 2019, 50(12): 12001-12006.

SHI Xiaoxiu, WU Xianzhe, MA Xingshuang, et al. Biomedical applications of tantalum-based materials and the underlying mechanisms [J]. Journal of Functional Materials, 2019, 50(12): 12001-12006.

石晓岫, 毛世龙, 刘洋, 等. 钽与钛(合金)骨科材料的差异比较:理化指标及抗菌和成骨能力 [J]. 中国组织工程研究, 2021, 25(4): 593-599.

SHIXiaoxiu, MAO Shilong, LIU Yang, et al. Comparison of tantalum and titanium(alloy)as orthopedic materials: physical and chemical indexes, antibacterial and osteogenic ability [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(4): 593-599.

NOURI A, ROHANI SHIRVAN A, LI Yuncang, et al. Additive manufacturing of metallic and polymeric load-bearing biomaterials using laser powder bed fusion: a review [J]. Journal of Materials Science Technology, 2021, 94: 196-215.

YANG Jiankai, GU Dongdong, LIN Kaijie, et al. Laser additive manufacturing of bio-inspired metallic structures [J]. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers, 2022, 1(1): 100013.

杨柳, 王富友. 医学3D打印多孔钽在骨科的应用 [J]. 第三军医大学学报, 2019, 41(19): 1859-1866.

YANG Liu, WANGFuyou. Progress of 3D printed porous tantalum in orthopedics [J]. Journal of Third Military Medical University, 2019, 41(19): 1859-1866.

MA Shuai, TANG Qian, HAN Xiaoxiao, et al. Manufacturability, mechanical properties, mass-transport properties and biocompatibility of triply periodic minimal surface(TPMS)porous scaffolds fabricated by selective laser melting [J]. Materials Design, 2020, 195: 109034.

SUKUMAR V R, GOLLA B R, SHAIK M A, et al. Modeling and characterization of porous tantalum scaffolds [J]. Transactions of the Indian Institute of Metals, 2019, 72(4): 935-949.

LIU Yindong, BAO Chongyun, WISMEIJER D, et al. The physicochemical/biological properties of porous tantalum and the potential surface modification techniques to improve its clinical application in dental implantology [J]. Materials Science and Engineering: C, 2015, 49: 323-329.

杨坤, 王建, 杨广宇, 等. 电子束选区熔化成形高强钽的组织与性能 [J]. 稀有金属材料与工程, 2023, 52(9): 3019-3025.

YANG Kun, WANG Jian, YANG Guangyu, et al. Microstructure and properties of high strength tantalum prepared by selective electron beam melting [J]. Rare Metal Materials and Engineering, 2023, 52(9): 3019-3025.

MURR L E. Metallurgy principles applied to powder bed fusion 3D printing/additive manufacturing of personalized and optimized metal and alloy biomedical implants: an overview [J]. Journal of Materials Research and Technology, 2019, 9(1): 1087-1103.

WANG Zhonggang. Recent advances in novel metallic honeycomb structure [J]. Composites: Part B Engineering, 2019, 166: 731-741.

YANG Lei, YAN Chunze, HAN Changjun, et al. Mechanical response of a triply periodic minimal surface cellular structures manufactured by selective laser melting [J]. International Journal of Mechanical Sciences, 2018, 148: 149-157.

CHEN Xueyan, JI Qingxiang, WEI Jianzheng, et al. Light-weight shell-lattice metamaterials for mechanical shock absorption [J]. International Journal of Mechanical Sciences, 2020, 169: 105288.

LIN Kaijie, HU Kaiming, GU Dongdong. Metallic integrated thermal protection structures inspired by the Norway spruce stem: design, numerical simulation and selective laser melting fabrication [J]. Optics Laser Technology, 2019, 115: 9-19.

YANG Nan, DU Chengfei, WANG Shoujun, et al. Mathematically defined gradient porous materials [J]. Materials Letters, 2016, 173: 136-140.

FENG Jiawei, FU Jianzhong, YAO Xinhua, et al. Triply periodic minimal surface(TPMS)porous structures: from multi-scale design, precise additive manufacturing to multidisciplinary applications [J]. International Journal of Extreme Manufacturing, 2022, 4(2): 022001.

孙亚迪, 马剑雄, 王岩, 等. 三周期极小曲面骨支架微观结构对支架性能的影响研究进展 [J]. 中国修复重建外科杂志, 2023, 37(10): 1314-1318.

SUN Yadi, MA Jianxiong, WANG Yan, et al. Research progress in influence of microstructure on performance of triply-periodic minimal surface bone scaffolds [J]. Chinese Journal of Reparative and Reconstructive Surgery, 2023, 37(10): 1314-1318.

BAI Yuchao, FU Fan, XIAO Zefeng, et al. Progress in selective laser melting equipment, related biomedical metallic materials and applications [J]. Journal of Zhejiang University: Science A, 2018, 19(2): 122-136.

BELDA R, MEGÍAS R, MARCO M, et al. Numerical analysis of the influence of triply periodic minimal surface structures morphometry on the mechanical response [J]. Computer Methods and Programs in Biomedicine, 2023, 230: 107342.

ZHANG Yijin, LIU Bin, PENG Fei, et al. Adaptive enhancement design of triply periodic minimal surface lattice structure based on non-uniform stress distribution [J]. Applied Mathematics and Mechanics, 2023, 44(8): 1317-1330.

LU Yongtao, ZHAO Wenying, CUI Zhentao, et al. The anisotropic elastic behavior of the widely-used triply-periodic minimal surface based scaffolds [J]. Journal of the Mechanical Behavior of Biomedical Materials, 2019, 99: 56-65.

MA Shuai, TANG Qian, ZHU Changbao, et al. Laser powder bed fusion-built Ti6Al4V bone scaffolds composed of sheet and strut-based porous structures: morphology, mechanical properties, and biocompatibility [J]. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers, 2022, 1(4): 100051.

AL-KETAN O, ROWSHAN R, ABU AL-RUB R K. Topology-mechanical property relationship of 3D printed strut, skeletal, and sheet based periodic metallic cellular materials [J]. Additive Manufacturing, 2018, 19: 167-183.

BIEMOND J E, AQUARIUS R, VERDONSCHOT N, et al. Frictional and bone ingrowth properties of engineered surface topographies produced by electron beam technology [J]. Archives of Orthopaedic and Trauma Surgery, 2011, 131(5): 711-718.

ZHANG Lei, FEIH S, DAYNES S, et al. Energy absorption characteristics of metallic triply periodic minimal surface sheet structures under compressive loading [J]. Additive Manufacturing, 2018, 23: 505-515.

吴先哲. 骨科植入用多孔钽激光3D打印成形工艺及生物力学性能研究 [D]. 北京: 机械科学研究总院, 2021.

ZHANG Yutao, AIYITI W, DU Shu, et al. Design and mechanical behaviours of a novel tantalum lattice structure fabricated by SLM [J]. Virtual and Physical Prototyping, 2023, 18(1): e2192702.

NOURI M, JALALI F, KARIMI G, et al. Image-based computational simulation of sub-endothelial LDL accumulation in a human right coronary artery [J]. Computers in Biology and Medicine, 2015, 62: 206-221.

ALI D, SEN S. Permeability and fluid flow-induced wall shear stress of bone tissue scaffolds: computational fluid dynamic analysis using Newtonian and non-Newtonian blood flow models [J]. Computers in Biology and Medicine, 2018, 99: 201-208.

ATAEE A, LI Yuncang, BRANDT M, et al. Ultrahigh-strength titanium gyroid scaffolds manufactured by selective laser melting(SLM)for bone implant applications [J]. Acta Materialia, 2018, 158: 354-368.

HONG J, CHA H, PARK Y, et al. Elastic moduli and Poisson's ratios of microscopic human femoral trabeculae [C]//11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007: 274-277.

SOLA A, BELLUCCI D, CANNILLO V. Functionally graded materials for orthopedic applications -an update on design and manufacturing [J]. Biotechnology Advances, 2016, 34(5): 504-531.

HAO Mingzhong, WEI Chengjian, LIU Xin, et al. Quantitative evaluation on mechanical characterization of Ti6Al4V porous scaffold designed based on Weaire-Phelan structure via experimental and numerical analysis methods [J]. Journal of Alloys and Compounds, 2021, 885: 160234.

TEO J C M, TEOH S H. Permeability study of vertebral cancellous bone using micro-computational fluid dynamics [J]. Computer Methods in Biomechanics and Biomedical Engineering, 2012, 15(4): 417-423.

NAUMAN E A, FONG K E, KEAVENY T M. Dependence of intertrabecular permeability on flow direction and anatomic site [J]. Annals of Biomedical Engineering, 1999, 27(4): 517-524.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

3D打印矩形粗糙通道内火箭煤油流动换热特性试验方法研究

一种快速3D打印分层方向确定算法

选区激光熔化激光能量在TC4粉末中分布特性研究

3D打印聚醚醚酮复合材料人工骨的成型参数优化

保留STL模型特征细节的3D打印自适应分层算法