IGZO薄膜晶体管生物传感器无标记检测强直性脊柱炎

吕腾博; 刘嘉乐; 刘丽; 李昕; 韩传余; 王小力

doi:10.7652/xjtuxb202402016

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IGZO薄膜晶体管生物传感器无标记检测强直性脊柱炎

更新时间：2025-05-13

- IGZO薄膜晶体管生物传感器无标记检测强直性脊柱炎
- Label-Free Detection of Ankylosing Spondylitis by IGZO Thin-Film Transistor Biosensor
- 西安交通大学学报 2024年58卷第2期页码：157-163
- 作者机构：
  
  1. 西安交通大学微电子学院,西安,710049
  2. 西安交通大学物理学院,西安,710049
  3. 沈阳大学师范学院,沈阳,110003
- 作者简介：
  
  : 2023-08-07。作者简介: 吕腾博(1996—),男,博士生
  王小力(通信作者),男,教授,博士生导师。基金项目: 国家自然科学基金资助项目(62174130)
- 基金信息：
  
  : 2023-08-07。作者简介: 吕腾博(1996—),男,博士生;王小力(通信作者),男,教授,博士生导师。基金项目: 国家自然科学基金资助项目(62174130);装备预研基金资助项目(2022-JCJQ-JJ-1099);陕西省重点研发计划资助项目(2023-YBSF-407)。
- DOI：10.7652/xjtuxb202402016
  中图分类号： TP212.3
- 网络首发：2024-02-10，
  
  纸质出版：2024
- 稿件说明：
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吕腾博, 刘嘉乐, 刘丽, 等. IGZO薄膜晶体管生物传感器无标记检测强直性脊柱炎[J]. 西安交通大学学报, 2024,58(2):157-163.

Label-Free Detection of Ankylosing Spondylitis by IGZO Thin-Film Transistor Biosensor[J]. 2024, 58(2): 157-163.
吕腾博, 刘嘉乐, 刘丽, 等. IGZO薄膜晶体管生物传感器无标记检测强直性脊柱炎[J]. 西安交通大学学报, 2024,58(2):157-163. DOI： 10.7652/xjtuxb202402016.

Label-Free Detection of Ankylosing Spondylitis by IGZO Thin-Film Transistor Biosensor[J]. 2024, 58(2): 157-163. DOI： 10.7652/xjtuxb202402016.

摘要

为了快速检测强直性脊柱炎血清学分子标志物人体白细胞抗原(HLA-B27)

开发了一种基于人体白细胞抗原B27(HLA-B27)功能化的氧化铟镓锌(IGZO)薄膜晶体管生物传感器。利用射频磁控溅射技术和微纳加工工艺制备了IGZO薄膜晶体管(IGZO TFT)

采用3-氨丙基三乙氧基硅烷(APTES)和抗体对IGZO TFT进行修饰

制备出针对HLA-B27检测的生物传感器。实验结果表明

功能化的IGZO TFT生物传感器具有稳定的电学特性和传感性能。传感器对HLA-B27的检测极限为1 pg/mL

在1 pg/mL至100 ng/mL的范围内均有良好的线性响应。这说明所设计的高性能生物传感器能够有效检测出强直性脊柱炎的标志物。此外

IGZO TFT可以扩展为传感器阵列平台

实现对某种疾病多种标志物的联合检测

在便携式床旁诊断设备的应用中具有巨大潜力。

Abstract

In this paper

the IGZO thin-film transistor biosensor based on functionalized human leukocyte antigen B27(HLA-B27)is developed for rapid detection of the HLA-B27

a serological molecular marker for ankylosing spondylitis. The fabrication of IGZO thin-film transistors(IGZO TFT)using radio-frequency magnetron sputtering technology and micro-nano-processing is described. The IGZO TFT is modified with 3-aminopropyltriethoxysilane(APTES)and antibodies to prepare biosensors for HLA-B27 detection. The experimental results show that the functionalized IGZO TFT biosensor has stable electrical characteristics and sensing performance. The sensor shows a detection limit of 1 pg/mL for HLA-B27

and its linear response within the concentration range of 1 pg/mL to 100 ng/mL is good. These results indicate that the proposed high-performance biosensor can effectively detect biomarker of ankylosing spondylitis. In addition

the IGZO TFT can be expanded into a sensor array platform to realize combined detection of multiple markers for a certain disease

which has great potential in the application of portable bedside diagnostic devices.

关键词

Keywords

references

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