生物玻璃陶瓷骨支架的光固化成形工艺与过固化研究

杨蒙蒙; 伍言龙; 许燕; 陈旭; 刘亚雄; 周建平

doi:10.7652/xjtuxb202209016

您当前的位置：

首页 >

文章列表页 >

生物玻璃陶瓷骨支架的光固化成形工艺与过固化研究

—————————————————————— | 更新时间：2025-07-09

- 生物玻璃陶瓷骨支架的光固化成形工艺与过固化研究
- Forming Process and Overcure of Bioglass Ceramic Bone Scaffold by Photocuring Technology
- 西安交通大学学报 2022年56卷第9期页码：151-159
- 作者机构：
  
  1. 新疆大学机械工程学院,乌鲁木齐,830017
  2. 季华实验室,广东,佛山,528200
  3. 西安交通大学机械制造系统工程国家重点实验室,西安,710049
- 作者简介：
  
  : 2022-03-25。作者简介: 杨蒙蒙(1997—),女,硕士生
  周建平(通信作者),男,教授,博士生导师。基金项目: 国家自然科学基金资助项目(52075421)
- 基金信息：
  
  : 2022-03-25。作者简介: 杨蒙蒙(1997—),女,硕士生;周建平(通信作者),男,教授,博士生导师。基金项目: 国家自然科学基金资助项目(52075421);广东省基础与应用基础研究基金资助项目(2020B1515130002);季华实验室建设资助项目
- DOI：10.7652/xjtuxb202209016
  中图分类号： TB321
- 网络首发：2022-09-10，
  
  纸质出版：2022
- 稿件说明：
移动端阅览
杨蒙蒙, 伍言龙, 许燕, 等. 生物玻璃陶瓷骨支架的光固化成形工艺与过固化研究[J]. 西安交通大学学报, 2022,56(9):151-159.

YANG Mengmeng, WU Yanlong, XU Yan, et al. Forming Process and Overcure of Bioglass Ceramic Bone Scaffold by Photocuring Technology[J]. 2022, 56(9): 151-159.
杨蒙蒙, 伍言龙, 许燕, 等. 生物玻璃陶瓷骨支架的光固化成形工艺与过固化研究[J]. 西安交通大学学报, 2022,56(9):151-159. DOI： 10.7652/xjtuxb202209016.

YANG Mengmeng, WU Yanlong, XU Yan, et al. Forming Process and Overcure of Bioglass Ceramic Bone Scaffold by Photocuring Technology[J]. 2022, 56(9): 151-159. DOI： 10.7652/xjtuxb202209016.

摘要

针对光固化技术制备生物玻璃陶瓷多孔骨支架中因光散射、光叠加等原因导致内孔扩散的过固化问题

提出从“孔-面-体”3个层面来探究样件成形过程中过固化现象与工艺参数间关系的方法

并逆向建立克服过固化提高精度的多孔补偿模型。首先

采用激光共聚焦测量了骨支架中单孔在不同曝光时间和石墨浓度下的过固化值与固化深度; 其次

在骨支架的面结构中采用光学影像测量仪分析了不同面孔隙率和孔隙形状下的过固化值与固化深度; 然后

使用场发射扫描电镜表征了重叠层厚对骨支架整体结构中固化特性的影响; 最后

通过控制骨支架的多孔尺寸

建立过固化逆向补偿模型并制备了与模型孔径相差不大于5 μm的多孔样件。采用所制备的多孔支架样件进行实验验证

结果表明:单孔结构中

过固化值和固化深度均随曝光时间的对数增加而线性增加

随石墨浓度增加而减小; 在单层面结构中

过固化值和固化深度均随孔隙率的增大线性减小

孔隙形状对固化深度无明显影响; 在体结构中

随重叠层厚的增加

样件过固化程度增加

叠加层厚10 μm为适宜分层; 在相同曝光时间和石墨浓度下

过固化从孔结构-面结构-体结构过程中逐渐增加

且孔和面结构的过固化程度显著大于体结构。该方法可为高精度多孔骨支架的制备提供一种新思路。

Abstract

To solve the problem of overcure caused by light scattering light superposition and others in production of bioglass ceramic porous bone scaffolds by using photocuring technology

a method based on the three levels of “pore-layer-volume” is proposed to explore the relationship between the overcure and process parameters in the forming process of such a scaffold. Moreover

a porous compensation model is established reversely to overcome overcure and improve accuracy. Firstly

the overcure value and curing depth of a single pore in the scaffold under different exposure time and graphite concentration are measured by laser confocal microscopy. Secondly

the overcure value and curing depth under different monolayer porosity and pore geometries are analyzed by optical image measuring instrument in the monolayer structure of the scaffold. Thirdly

the influence of overlapping layer thickness on the curing behaviour is characterized by field emission scanning electron microscopy in the volume structure. Finally

an overcure reverse compensation model is established by controlling the porous size of the scaffold

and a porous test sample with a diameter error less than 5 μm is produced. The prepared porous scaffolds are used for experimental verification. The results show that the overcure value and the curing depth linearly increase with the logarithmic increase of the exposure time but decrease with the increase of the graphite concentration in the single-pore structure

the overcure value and the curing depth linearly decrease with the increase of the monolayer porosity

and the pore geometries have no obvious influence on the curing depth in the monolayer structure

the overcure degree increases with the increase of overlapping layer thickness

and a thickness of 10 μm can be suitable for forming in the volume structure. When both the exposure time and the graphite concentration are the same

the overcure gradually increases for the single-pore structure

the layer structure and the volume structure

and the overcure degree in the formation of the pore structure and the layer structure is significantly greater than that of the volume structure. The proposed method can provide a new idea for the preparation of high-precision porous bone scaffold

关键词

Keywords

references

黄淼俊, 伍海东, 黄容基, 等. 陶瓷增材制造(3D打印)技术研究进展 [J]. 现代技术陶瓷, 2017, 38(4): 248-266.

HUANG Miaojun, WU Haidong, HUANG Rongji, et al. A review on ceramic additive manufacturing(3D printing)[J]. Advanced Ceramics, 2017, 38(4): 248-266.

FENG Pei, WU Ping, GAO Chengde, et al. A multimaterial scaffold with tunable properties: toward bone tissue repair [J]. Advanced Science, 2018, 5(6): 1700817.

SONG S Y, PARK M S, LEE D, et al. Optimization and characterization of high-viscosity ZrO2 ceramic nanocomposite resins for supportless stereolithography [J]. Materials Design, 2019, 180: 107960.

赵广宾, 安超, 秦勉, 等. 聚醚醚酮/羟基磷灰石复合植入物的制备及性能研究 [J]. 西安交通大学学报, 2019, 53(4): 72-78.

ZHAO Guangbin, AN Chao, QIN Mian, et al. Preparation and performance study of polyetheretherketone/hydroxyapatite composite implants [J]. Journal of Xi'an Jiaotong University, 2019, 53(4): 72-78.

MA Hongshi, FENG Chun, CHANG Jiang, et al. 3D-printed bioceramic scaffolds: from bone tissue engineering to tumor therapy [J]. Acta Biomaterialia, 2018, 79: 37-59.

LI Xiang, ZHANG Hang, SHEN Yifan, et al. Fabrication of porous β-TCP/58S bioglass scaffolds via top-down DLP printing with high solid loading ceramic-resin slurry [J]. Materials Chemistry and Physics, 2021, 267: 124587.

刘雨, 陈张伟. 陶瓷光固化3D打印技术研究进展 [J]. 材料工程, 2020, 48(9): 1-12.

LIU Yu, CHEN Zhangwei. Research progress in photopolymerization-based 3D printing technology of ceramics [J]. Journal of Materials Engineering, 2020, 48(9): 1-12.

JANG K J, KANG J H, SAKTHIABIRAMI K, et al. Evaluation of cure depth and geometrical overgrowth depending on zirconia volume fraction using digital light processing [J]. Journal of Nanoscience and Nanotechnology, 2019, 19(4): 2154-2157.

WU Haidong, LIU Wei, HE Rongxuan, et al. Fabrication of dense zirconia-toughened alumina ceramics through a stereolithography-based additive manufacturing [J]. Ceramics International: Part B, 2017, 43(1): 968-972.

KOMISSARENKO D A, SOKOLOV P S, EVSTIGNEEVA A D, et al. Rheological and curing behavior of acrylate-based suspensions for the DLP 3D printing of complex zirconia parts [J]. Materials, 2018, 11(12): 2350.

李腾飞, 伍言龙, 赵广宾, 等. 多孔硅酸钙/明胶复合支架制备工艺及力学性能研究 [J]. 西安交通大学学报, 2021, 55(4): 172-180.

LI Tengfei, WU Yanlong, ZHAO Guangbin, et al. Fabrication process and mechanical performance of porous calcium silicate/gelatin composite scaffold [J]. Journal of Xi'an Jiaotong University, 2021, 55(4): 172-180.

杨蒙蒙, 伍言龙, 赵广宾, 等. 可吸收生物玻璃陶瓷/聚己内酯复合接骨板的制备工艺及力学性能 [J]. 西安交通大学学报, 2021, 55(3): 155-163.

YANG Mengmeng, WU Yanlong, ZHAO Guangbin, et al. Preparation process and mechanical properties of absorbable biological glass ceramic/polycaprolactone composite bone plate [J]. Journal of Xi'an Jiaotong University, 2021, 55(3): 155-163.

ZENG Yong, YAN Yinzhou, YAN Hengfeng, et al. 3D printing of hydroxyapatite scaffolds with good mechanical and biocompatible properties by digital light processing [J]. Journal of Materials Science, 2018, 53(9): 6291-6301.

MITTERAMSKOGLER G, GMEINER R, FELZMANN R, et al. Light curing strategies for lithography-based additive manufacturing of customized ceramics [J]. Additive Manufacturing, 2014, 1/2/3/4: 110-118.

LASGORCEIX M, CHAMPION E, CHARTIER T. Shaping by microstereolithography and sintering of macro-micro-porous silicon substituted hydroxyapatite [J]. Journal of the European Ceramic Society, 2016, 36(4): 1091-1101.

HUA Shuaibin, SU Jin, DENG Zelin, et al. Microstructures and properties of 45S5 bioglass BCP bioceramic scaffolds fabricated by digital light processing [J]. Additive Manufacturing, 2021, 45: 102074.

PARK I B, HA Y M, LEE S H. Still motion process for improving the accuracy of latticed microstructures in projection microstereolithography [J]. Sensors and Actuators: A Physical, 2011, 167(1): 117-129.

LIMAYE A, ROSEN D, WOODRUFF G W. Process planning to build Mask Projection Stereolithography parts with accurate vertical dimensions [C]∥2007 International Solid Freeform Fabrication Symposium. Austin, USA: [s.n.], 2007: 159-173.

CHARTIER T, DUPAS C, GEFFROY P M, et al. Influence of irradiation parameters on the polymerization of ceramic reactive suspensions for stereolithography [J]. Journal of the European Ceramic Society, 2017, 37(15): 4431-4436.

GENTRY S P, HALLORAN J W. Depth and width of cured lines in photopolymerizable ceramic suspensions [J]. Journal of the European Ceramic Society, 2013, 33(10): 1981-1988.

LI Yanhui, CHEN Yong, WANG Minglang, et al. The cure performance of modified ZrO2 coated by paraffin via projection based stereolithography [J]. Ceramics International, 2019, 45(3): 4084-4088.

WU Yanlong, CHEN Ruomeng, ZHAO Guangbin, et al. Effect of graphite particles as additive on the curing behaviour of β-tricalcium phosphate suspensions and scaffold fabrication by digital light processing [J]. Journal of the European Ceramic Society, 2020, 40(12): 4323-4331.

GENTRY S P, HALLORAN J W. Absorption effects in photopolymerized ceramic suspensions [J]. Journal of the European Ceramic Society, 2013, 33(10): 1989-1994.

TOMECKOVA V, HALLORAN J W. Predictive models for the photopolymerization of ceramic suspensions [J]. Journal of the European Ceramic Society, 2010, 30(14): 2833-2840.

CHARTIER T, DUTERTE C, ABOULIATIM Y, et al. Net-shape forming of complex ceramic parts with a high dimensional resolution: stereo-and microstereo-lithography [C]∥10th International Conference and Exhibition of the European Ceramic Society. Berlin, Germany: [s.n.], 2007: 646-651.

GENTRY S P, HALLORAN J W. Light scattering in absorbing ceramic suspensions: effect on the width and depth of photopolymerized features [J]. Journal of the European Ceramic Society, 2015, 35(6): 1895-1904.

WU Xiangquan, LIAN Qin, LI Dichen, et al. Influence of boundary masks on dimensions and surface roughness using segmented exposure in ceramic 3D printing [J]. Ceramics International, 2019, 45(3): 3687-3697.

KANG H W, PARK J H, CHO D W. A pixel based solidification model for projection based stereolithography technology [J]. Sensors and Actuators: A Physical, 2012, 178: 223-229.

LI Xinyi, HU Kehui, LU Zhigang. Effect of light attenuation on polymerization of ceramic suspensions for stereolithography [J]. Journal of the European Ceramic Society, 2019, 39(7): 2503-2509.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

超临界水异常区域热力学特性研究

扇贝仿生密封腔室内超临界二氧化碳泄漏流湍动能耗散机理研究

多工况下离心压气机叶轮-机匣一体联合设计优化

张角凹坑气膜孔对双层壁气膜冷却特性的影响

三塔合一间接空冷系统结构参数对夏季运行特性的影响研究