可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型

阮春标; 胡经纬; 袁恒迪; 郭培哲; 董光能

doi:10.7652/xjtuxb202206012

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可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型

—————————————————————— | 更新时间：2025-04-27

- 可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型
- Creep Release Properties and Theoretical Models of Hydrogel for Artificial Joint Lubrication
- 西安交通大学学报 2022年56卷第6期页码：97-103
- 作者机构：
  
  西安交通大学现代设计及转子轴承系统教育部重点实验室,西安,710049
- 作者简介：
  
  : 2021-11-08。作者简介: 阮春标(1996—),男,硕士生
  董光能(通信作者),男,教授。基金项目: 国家自然科学基金资助项目(51975454)
- 基金信息：
  
  : 2021-11-08。作者简介: 阮春标(1996—),男,硕士生;董光能(通信作者),男,教授。基金项目: 国家自然科学基金资助项目(51975454)
- DOI：10.7652/xjtuxb202206012
  中图分类号： TH117
- 网络首发：2022-06-10，
  
  纸质出版：2022
- 稿件说明：
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阮春标, 胡经纬, 袁恒迪, 等. 可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型[J]. 西安交通大学学报, 2022,56(6):97-103.

RUAN Chunbiao, HU Jingwei, YUAN Hengdi, et al. Creep Release Properties and Theoretical Models of Hydrogel for Artificial Joint Lubrication[J]. 2022, 56(6): 97-103.
阮春标, 胡经纬, 袁恒迪, 等. 可用于人工关节润滑的水凝胶蠕变缓释性能及理论模型[J]. 西安交通大学学报, 2022,56(6):97-103. DOI： 10.7652/xjtuxb202206012.

RUAN Chunbiao, HU Jingwei, YUAN Hengdi, et al. Creep Release Properties and Theoretical Models of Hydrogel for Artificial Joint Lubrication[J]. 2022, 56(6): 97-103. DOI： 10.7652/xjtuxb202206012.

摘要

针对人工关节润滑液难以定量供给导致假体表面磨损严重的问题

提出一种水凝胶关节囊结构来供给和保存关节润滑液的方法

并进行了试验探究和理论验证。首先

制备了含透明质酸琼脂糖水凝胶

在生理盐水浸润环境中对其进行了体外无侧限压缩蠕变缓释试验

得到了蠕变体积和介质释放量与压力的关系曲线

并得出蠕变体积与介质释放量的转换公式。然后

根据水凝胶的结构和性质

建立了耦合扩散和大变形理论的本构模型

在给定压力的情况下通过该模型可得到水凝胶蠕变仿真曲线

最后结合试验得到的转化公式

可推导出水凝胶介质缓释量。采用一种将试验结果与有限元建模和优化方法相结合的有限元逆向法技术

得到了试件的相关材料参数

使用该参数对不同压力下的蠕变行为进行了仿真验证

结果表明:含透明质酸琼脂糖水凝胶在恒定压力作用下蠕变缓释量正比于蠕变体积; 在给定压力和作用时间的情况下

耦合扩散和大变形理论模型可以在误差允许范围内定量预测含透明质酸琼脂糖水凝胶的缓释量。该研究成果可为未来水凝胶作为人造关节囊实现人工关节定量润滑提供参考。

Abstract

Aiming at the problems of difficult quantitative supply of the lubricant in artificial joint

resulting in serious wear of prosthesis surface a method for supplying and preserving joint lubricant by using hydrogel to simulate the structure of articular capsule is proposed

experimental exploration and theoretical verification are carried out. Firstly

the hyaluronic acid agar hydrogel is prepared

and the unconfined compression creep release test is carried out in the saline immersion environment. The relationship curves between creep volume

medium release and pressure are obtained

and the conversion formula between creep volume and medium release is obtained. Then

based on the structure and properties of hydrogels

a constitutive model of coupled diffusion and large deformation theory is established

under the given pressure condition

the creep curve of hydrogel can be obtained through the model. Finally

the release rate of gel medium can be deduced from the transformation formula obtained from the experiment. A finite element inverse method technology combining the test results with the finite element modeling and optimization method is used to obtain the material parameters of the experimental sample

which are used to simulate the creep behavior under different pressures

the results show that the creep release volume of hyaluronic acid agar hydrogel under constant pressure is proportional to the creep volume. Under the given pressure and action time

the coupled diffusion and large deformation theoretical models can quantitatively predict the release quantity of hyaluronic acid agar hydrogel within the permissible range of error. The research results can provide references for future hydrogel as artificial joint capsule for quantitative lubrication of artificial joints.

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references

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