多孔硅酸钙/明胶复合支架制备工艺及力学性能研究

李腾飞 1; 伍言龙 1; 赵广宾 1; 周昱 1; 刘亚雄 3; 高琳 1; 2; 丁信智 4

doi:10.7652/xjtuxb202104019

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多孔硅酸钙/明胶复合支架制备工艺及力学性能研究

更新时间：2025-07-09

- 多孔硅酸钙/明胶复合支架制备工艺及力学性能研究
- Fabrication Process and Mechanical Performance of Porous Calcium Silicate/Gelatin Composite Scaffold
- 西安交通大学学报 2021年55卷第4期页码：172-180
- 作者机构：
  
  1. 西安交通大学机械制造系统工程国家重点实验室,西安,710049
  2. 西安交通大学机械工程学院,西安,710049
- 作者简介：
- 基金信息：
  
  : 2020-07-25。作者简介: 李腾飞(1996—),男,硕士生;刘亚雄(通信作者),男,教授,博士生导师。基金项目: 国家重点研发计划资助项目(2018YFB1106904);国家自然科学基金资助项目(52075421);季华实验室建设资助项目(X200031 TM200)
- DOI：10.7652/xjtuxb202104019
  中图分类号： TQ174.5
- 网络首发：2021-04-10，
  
  纸质出版：2021
- 稿件说明：
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李腾飞 1, 伍言龙 1, 赵广宾 1, 等. 多孔硅酸钙/明胶复合支架制备工艺及力学性能研究[J]. 西安交通大学学报, 2021,55(4):172-180.

Fabrication Process and Mechanical Performance of Porous Calcium Silicate/Gelatin Composite Scaffold[J]. 2021, 55(4): 172-180.
李腾飞 1, 伍言龙 1, 赵广宾 1, 等. 多孔硅酸钙/明胶复合支架制备工艺及力学性能研究[J]. 西安交通大学学报, 2021,55(4):172-180. DOI： 10.7652/xjtuxb202104019.

Fabrication Process and Mechanical Performance of Porous Calcium Silicate/Gelatin Composite Scaffold[J]. 2021, 55(4): 172-180. DOI： 10.7652/xjtuxb202104019.

摘要

针对可控复杂孔隙结构的多孔生物陶瓷支架难以通过传统方法制备、强度低、脆性大等问题

提出了一种将光固化工艺和渗透明胶工艺相结合的方法

制备了具有优异力学性能的多孔硅酸钙/明胶复合支架。通过扫描电子显微镜研究了不同明胶质量浓度复合支架的微观结构

探讨了明胶溶液质量浓度对多孔硅酸钙/明胶复合支架Z向和X-Y向力学性能的影响规律。结果表明:渗透明胶后

明胶填充了支架的部分微观孔隙并涂覆在支架表面。当明胶质量分数为5%和7.5%时

试样宏观孔隙连通性较好

强度和韧性得到了明显提高。此质量浓度范围下复合支架仍存在各向异性

在Z向的压缩强度提高了0.63～1.67倍

最高达到5.91 MPa

应力能密度提高了0.84～1.77倍

最高达到530×10

J/m

; X-Y向的压缩强度提高了1.56～2.07倍

最高达到10.01 MPa

应力能密度提高了1.51～3.33倍

最高达到10.75×10

J/m

。因此

明胶质量分数为5%～7.5%是制备多孔硅酸钙/明胶复合支架的合适浓度。

Abstract

To solve the poor mechanical performance and difficulty of fabrication of controllable complex porous bioceramic bone scaffolds by traditional methods

porous calcium silicate/gelatin composite scaffolds with excellent mechanical performance were developed with a two-step process: fabricating the porous calcium silicate scaffolds by digital light processing(DLP); immersing the porous calcium silicate scaffolds into a gelatin melt. The microstructure of composite scaffolds with different gelatin contents was observed by scanning electron microscope. The effects of gelatin contents on the mechanical performa

nce in Z and X-Y directions of the porous calcium silicate/gelatin composite scaffolds were analyzed. The results show that gelatin fills the microscopic pores and coats the surface of the scaffolds. When the gelatin mass fraction gets 5% and 7.5%

the samples are endowed with good pore connectivity

mechanical strength and toughness. However

the composite scaffolds still exhibit mechanical anisotropy. The compressive strength and strain energy density in the Z direction are increased by 0.63-1.67 times to 5.91 MPa and by 0.84-1.77 times to 5.30×10

J/m

respectively. The compressive strength and strain energy density in the X-Y direction are increased by 1.56-2.07 times to 10.01 MPa and by 1.51-3.33 times to 10.75×10

J/m

respectively. Thus

the appropriate gelatin content for preparing porous calcium silicate/gelatin composite scaffold is chosen as 5%-7.5%.

关键词

Keywords

references

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