颈内动脉狭窄时Willis环的血液动力学数值模拟

陈珍 1; 袁奇 1; 朱光宇 1; 刘伟阳 1; 杨健 2

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颈内动脉狭窄时Willis环的血液动力学数值模拟

更新时间：2025-07-09

- 颈内动脉狭窄时Willis环的血液动力学数值模拟
- Blood Flow Dynamics in Patient-Specific Circle of Willis Model with Severe Internal Carotid Artery Stenosis
- 西安交通大学学报 2009年43卷第10期页码：119-123
- 作者机构：
  
  西安交通大学能源与动力工程学院,西安,710049
- 作者简介：
- 基金信息：
  
  : 2009-04-23. 作者简介: 陈珍(1980-),女,硕士生;袁奇(联系人),男,教授,博士生导师. 基金项目: 国家自然科学基金资助项目(10672131);教育部留学归国人员科研启动基金资助项目[2006]
- DOI：
  中图分类号： Q811.2
- 网络首发：2009-10-10，
  
  纸质出版：2009
- 稿件说明：
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陈珍 1, 袁奇 1, 朱光宇 1, 等. 颈内动脉狭窄时Willis环的血液动力学数值模拟[J]. 西安交通大学学报, 2009,43(10):119-123.

Blood Flow Dynamics in Patient-Specific Circle of Willis Model with Severe Internal Carotid Artery Stenosis[J]. 2009, 43(10): 119-123.
陈珍 1, 袁奇 1, 朱光宇 1, 等. 颈内动脉狭窄时Willis环的血液动力学数值模拟[J]. 西安交通大学学报, 2009,43(10):119-123. DOI：

Blood Flow Dynamics in Patient-Specific Circle of Willis Model with Severe Internal Carotid Artery Stenosis[J]. 2009, 43(10): 119-123. DOI：

摘要

为检验Willis环的侧支循环能力

以及在动脉内膜切除手术(CEA)中颈内动脉(ICA)被夹闭前后环内的血液动力学变化情况

利用CT扫描数据以及计算机辅助设计软件建立了某病人的三维Willis环模型

在右侧颈内动脉(RICA)处人为地构建了一系列不同程度狭窄的模型.将血液模拟为非牛顿流体

采用ANSYS-CFX软件对Willis环内的血液稳态流动进行了三维数值模拟.计算结果表明

当狭窄率大于50%时

环内血液重新分配

前交通动脉(ACoA)侧支循环作用比后交通动脉(PCoA)更加重要.在CEA过程中

压力与脑部总血流量成正比.对于ACoA缺失的Willis环

只通过提升压力并不能有效增加脑部供血

术中可以考虑进行分流.研究结果对于临床具有一定的应用价值.

Abstract

Focusing the capacity of the circle of Willis(CoW)and the cerebral hemodynamic changes before and after clamping internal carotid artery(ICA)during carotid endarterectomy(CEA)

a 3D computational model was developed combining patient-specific CT images with CAD software. A series of different axisymmetric stenosis were artificially inserted in right internal carotid artery(RICA). Non-Newtonian blood flow in CoW was simulated under steady flow condition by ANSYS-CFX. The results show that cerebral blood flow gets redistributed as the degree of stenosis is greater than 50%. Collateral flow in anterior communicating artery(ACoA)is much more important than that in posterior communicating artery(PCoA). As cerebral blood flow(CBF)is proportional to blood pressure

raising blood pressure facilitates improving the cerebral blood supply efficiently during the CEA operation. However

while ACoA missing

the blood supply can not be simply maintained by raising blood pressure

a shunt is necessary.

关键词

Keywords

references

BARNETT H J M, GUNTON R V, ELIASZIW M, et al. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis [J]. Journal of the American Medical Association,2000, 283(11): 1429-1436.

周定标. 颈动脉内膜切除[M]. 北京: 人民军医出版社, 2005: 58-59.

BLASER T, HOFMANN K, BUERGER T, et al. Risk of stroke, transient ischemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stenosis [J]. Stroke,2002, 33(4): 1057-1062.

CEBRAL J R, CASTRO M A, SOTO O, et al. Blood-flow models of the circle of Willis from magnetic resonance data [J]. Journal of Engineering Mathematics,2003, 47(3/4): 369-386.

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LONG Q, LUPPI L, KONIG C S, et al. Study of the collateral capacity of the circle of Willis of patients with severe carotid artery stenosis by 3D computational modeling [J]. Journal of Biomechanics,2008, 41(12): 2735-2742.

JOHNSON B M, JOHNSON P R, CORNEY S, et al. Non-Newtonian blood flow in human right coronary arteries: steady state simulations [J]. Journal of Biomechanics, 2004, 37(5): 709-720.

张致身. 人脑血管解剖与临床[M]. 2版. 北京:科学技术文献出版社, 2004: 397-408.

陈珍,袁奇,申娜,等. 颅内Willis环三维稳态及非稳态血液动力学计算 [J]. 西安交通大学学报,2008,42(4):492-496.

CHEN Zhen,YUAN Qi,SHEN Na,et al. 3D steady/unsteady blood flow in the circle of willis[J].Journal of Xi'an Jiaotong University, 2008,42(4):492-496.

Alastruey J, Parker K H, Peiro J, et al. Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows [J]. Journal of Biomechanics,2007, 40(8): 1794-1805.

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