肾源分配网络的局内交换机制设计

许晓雯 1; 2; 王嘉寅 3; 4; 唐佩佳 4; 王玉珏 5

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肾源分配网络的局内交换机制设计

更新时间：2025-07-09

- 肾源分配网络的局内交换机制设计
- Online Exchange Mechanism of Organ Network
- 西安交通大学学报 2010年44卷第4期页码：23-27
- 作者机构：
  
  1. 西安交通大学管理学院,西安,710049
  2. 西安交通大学过程控制与效率工程教育部重点实验室,西安,710049
- 作者简介：
- 基金信息：
  
  : 2009-07-07. 作者简介: 许晓雯(1955-), 女, 副研究员. 基金项目: 国家自然科学基金资助项目(70702030)
- DOI：
  中图分类号： TP312
- 网络首发：2010-04-10，
  
  纸质出版：2010
- 稿件说明：
移动端阅览
许晓雯 1, 2, 王嘉寅 3, 等. 肾源分配网络的局内交换机制设计[J]. 西安交通大学学报, 2010,44(4):23-27.

Online Exchange Mechanism of Organ Network[J]. 2010, 44(4): 23-27.
许晓雯 1, 2, 王嘉寅 3, 等. 肾源分配网络的局内交换机制设计[J]. 西安交通大学学报, 2010,44(4):23-27. DOI：

Online Exchange Mechanism of Organ Network[J]. 2010, 44(4): 23-27. DOI：

摘要

通过考虑有配型不合适的肾捐赠者的患者

同时为了最大化患者的整体疗效

发掘潜在的肾源数量

提出了一种肾源分配网络的局内交换机制.机制设有2个缓冲池

分别存放普通患者和失去活体捐赠者的患者的信息

而有捐赠者但配型不合适的患者等待进入缓冲池.通过寻找患者与活体捐赠者之间的交换圈实现活体肾源交换; 通过寻找涵盖普通患者的交换路径同时结合常规肾源

实施分配.在法律允许的情况下

该机制能够通过提升患者的优先等级继续发掘潜在的肾资源.竞争分析结果显示

分配交换机制的竞争比的数学期望受配型概率分布的影响

并依概率收敛

患者的总误配数期望收敛于最优值数学期望的3.13倍

机制的改进比仿真平均值为2.80

平均白细胞抗原错配位点下降35.6%.

Abstract

An online exchange mechanism is proposed based on the kidney assignment network to maximize both the post-operation benefits of patients and the number of potential kidney resources when some patients have living donors who are not suitable in clinical experiments. Two buffers are built up to sort the information of common patients and those who loss living donors

separately. The pairs of patients and their un-suitable donors are waiting to enter the buffers. The exchange circles are checked firstly to implement exchanges among patients and living donors. Then the exchange route covering common patients is considered to make both assignment and exchange

and all patients and traditional kidney resources are taking into account in assignment. The mechanism is able to find out more resources through rising the priority levels of patients under allowance of laws. The result of competitive analysis shows that the mathematical expectation competitive rate is influenced by HLAmm distribution

is p.d. to certain value in theory

and the assignment network can control the expectation of HLAmm sum in 3.13 times of optimal one. The average improvement rate is 2.80

that means

average of HLAmm will decrease 35.6% by using the proposed mechanism.

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references

王嘉寅, 许晓雯. 局内肾资源接受决策问题的竞争分析 [J]. 西安交通大学学报, 2008, 42(4): 423-426.

WANG Jiayin, XU Xiaowen. Competitive analysis about online problem of kidney transplantation acceptance decision-making [J]. Journal of Xi'an Jiaotong University, 2008, 42(4): 423-426.

RAPAPORT F T. The case for a living emotionally related international kidney donor exchange registry [J]. Transplantation Proceedings, 1986(3): 5-9.

AHN J H, HORNBERGER J C. Involving patients in the cadaveric kidney transplant allocation process: a decision theoretic perspective[J]. Management Science, 1996, 42(5): 629-641.

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HOWARD D H. Why do transplant surgeons turn down organs? a model of the accept reject decision [J]. Journals of Health Economy, 2002, 21(6): 957-969.

ZENIOS S A. Optimal control of a paired-kidney exchange program [J]. Management Science, 2002,48(3): 328-342.

WANG Yujue, WANG Jiayin, TANG Peijia, et al. An efficient and impartial online algorithm for kidney assignment network[J]. Journal of Xi'an Jiaotong University(English Editor), 2009(1): 17-21.

张博. 相依随机变量列的随机和的中心极限问题 [J]. 数学学报, 2002, 45(3): 535-544.

ZHANG Bo. Central limit problem for random sums of dependent random variables[J]. Acta Mathematica Sinica, 2002, 45(3): 535-544.

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