一种提供容错性保障的药物设计网格环境

王永剑 1; 任一楠 1; 陈婷 1; 黄远强 1; 于坤千 2; 栾钟治 1; 蒋华良 2; 钱德沛 1; 3

您当前的位置：

首页 >

文章列表页 >

一种提供容错性保障的药物设计网格环境

更新时间：2025-07-09

- 一种提供容错性保障的药物设计网格环境
- A Drug Discovery Grid Environment with Fault-Tolerance Support
- 西安交通大学学报 2009年43卷第12期页码：21-25
- 作者机构：
  
  北京航空航天大学计算机学院,北京,100191
- 作者简介：
- 基金信息：
  
  : 2009-03-17. 作者简介: 王永剑(1981-),男,博士生;钱德沛(联系人),男,教授,博士生导师. 基金项目: 欧盟FP6资助项目(045609);国家高技术研究发展计划资助项目(2006AA01A106, 2006AA01A124, 2006AA01A118)
- DOI：
  中图分类号： TP391.9
- 网络首发：2009-12-10，
  
  纸质出版：2009
- 稿件说明：
移动端阅览
王永剑 1, 任一楠 1, 陈婷 1, 等. 一种提供容错性保障的药物设计网格环境[J]. 西安交通大学学报, 2009,43(12):21-25.

A Drug Discovery Grid Environment with Fault-Tolerance Support[J]. 2009, 43(12): 21-25.
王永剑 1, 任一楠 1, 陈婷 1, 等. 一种提供容错性保障的药物设计网格环境[J]. 西安交通大学学报, 2009,43(12):21-25. DOI：

A Drug Discovery Grid Environment with Fault-Tolerance Support[J]. 2009, 43(12): 21-25. DOI：

摘要

针对药物虚拟筛选操作运行时间长、易出错等问题

设计并实现了药物设计网格(DDGrid)

有效聚合了中国国家网格环境中闲散的资源

形成了支持高通量药物虚拟筛选的网格环境.所设计的DDGrid网格实现了基于复杂事件处理技术的有状态故障检测机制

通过持续分析节点间交互的事件流

定位可能的故障场景并触发相应的补偿操作来减少故障导致的损失

为系统提供了容错性保障.实验结果表明

有故障检测机制可以通过监测筛选任务运行情况对超时阀值进行动态调整

使得任务实际完成时间和理论完成时间之间的差值保持在10% 以内

同时提高了底层计算资源的利用率.

Abstract

In order to resolve the long running and error-prone problems in virtual screening

a drug discovery grid(DDGrid)is designed and implemented to establish a grid environment. The environment utilizes idle resources scattered over the CNGrid environment to support high-throughput virtual screening. The DDGrid implements stateful fault detection mechanism based on a complex event processing technology

and provides fault-tolerance support through continuously analyzing the exchanging event streams among different nodes

locating possible faulty situations and triggering the corresponding compensating operations to minimize the possible loss. Experimental results show that the fault detection mechanism keeps the difference between the actual task process time and the theoretical value within 10% through adjusting timeout threshold in the runtime

and improves the usage of underlying computing resources.

关键词

Keywords

references

QIAN Depei.CNGrid: a test-bed for grid technologies in China[C]∥Proceedings of the 10th IEEE International Workshop on Future Trends of Distributed Computing Systems.Piscataway,NJ,USA:IEEE,2004:135-139.

卢锡城,王怀民,王戟.虚拟计算环境iVCE:概念与体系结构 [J].中国科学(E 辑:信息科学),2006,36(10):1081-1099.

LU Xicheng, WANG Huaimin,WANG Ji. Virtual computing environment iVCE: concept and architecture [J]. Science in China(Series E:Information Sciences), 2006, 36(10):1081-1099.

LI Honglin, LI Chunlian, GUI Chunshan, et al.GAsDock: a new approach for rapid flexible docking based on an improved multi-population genetic algorithm [J]. Bioorg Med Chem Lett, 2004, 14(18):4671-4676.

SAHNI S.Scheduling master-slave multiprocessor systems [J]. IEEE Transactions on Computers, 1996, 45(10): 1195-1199.

GUNJAN K,IGNACIO L,FAHAD A,et al.Stateful detection in high throughput distributed systems [C]∥Proceedings of the 26th IEEE International Symposium on Reliable Distributed Systems. Piscataway, NJ, USA: IEEE, 2007: 275-287.

孟小峰,周龙骧,王珊.数据库技术发展趋势[J]. 软件学报,2004,15(12):1822-1836.

MENG Xiaofeng, ZHOU Longxiang, WANG Shan. State of the art and trends in database research [J]. Journal of Software, 2004, 15(12): 1822-1836.

金澈清,钱卫宁,周傲英.流数据分析与管理综述[J]. 软件学报,2004,15(08):1172-1181.

JIN Cheqing, QIAN Weining, ZHOU Aoying. Analysis and management of streaming data: a survey [J]. Journal of Software, 2004, 15(8): 1172-1181.

WU E,DIAO Yanlei, SHARIQ R.High-performance complex event processing over streams [C]∥Proceeding of the 25th ACM SIGMOD International Conference on Management of Data/Principles of Database Systems. New York, USA: ACM, 2006: 407-418.

WALKER W, MIREK R, JOHANNES G, el at.What is “next” in event processing? [C]∥Proceeding of the 26th ACM SIGMOD International Conference on Management of Data/Principles of Database Systems.New York, USA: ACM, 2007: 263-272.

BRUNO N,KOUDAS N,SRIVASTAVA D.Holistic twig joins: optimal XML pattern matching [C]∥Proceeding of the 21st ACM SIGMOD International Conference on Management of Data/Principles of Database Systems. New York, USA: ACM, 2002: 310-321.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

超临界二氧化碳向心透平轮背间隙内风阻损失及流动特性研究

张角凹坑气膜孔对双层壁气膜冷却特性的影响

不同板叠材料热声热机能量转换过程数值模拟研究

冷库水平空气幕热湿阻隔性能数值模拟研究

采用机器学习的大规模并行程序I/O性能建模与预测方法