1. 中国科学院上海微系统与信息技术研究所,上海,200050
2. 中国科学院研究生院,北京,100039
网络首发:2010-07-10,
纸质出版:2010
移动端阅览
朱壮晖 1, 周亮 1, 周洪波 1, 等. 聚酰亚胺基柔性神经微电极的优化[J]. 西安交通大学学报, 2010,44(7):85-89.
Optimization of Polyimide-Based Flexible Neural Microelectrode[J]. 2010, 44(7): 85-89.
对一种聚酰亚胺基柔性神经微电极进行了结构及制作工艺等方面的优化.针对动物视网膜的刺激
设计制作了具有固定通孔结构的柔性神经微电极.在制作工艺方面
使用空气等离子体表面处理以增强金属层的黏附性
降低了微电极的界面阻抗
增强了微电极稳定性
使之适于长期植入.优化后微电极的电极金属层牢固且具有较低的界面阻抗(43 kΩ)
比处理前降低了25.4%
误差减小了约4/5
具有良好的实用性.
The geometry and fabrication of polyimide-based flexible neural microelectrodes were optimized. Aiming at retinal prosthesis
several thru-holes were designed in the flexible neural microelectrode for fixating the electrode during implantation. And a plasma treatment was employed in the fabrication procedure to improve the adhesion of metal layer on the polymer for a long-term implantation. The optimized flexible microelectrode shows stronger adhesion
25.4% lower interface impedance(43 kΩ)
and a four fifths reduction of error.
周洪波,李刚,张华,等. 简易低成本柔性神经微电极制作方法 [J]. 光学精密工程, 2007, 15(7): 1056-1063.
ZHOU Hongbo, LI Gang, ZHANG Hua, et al. A simple and low-cost method to fabricate flexible microelectrodes for neural applications [J]. Optics and Precision Engineering, 2007,15(7):1056-1063.
孙晓娜,周洪波,李刚,等. 三维柔性神经微电极阵列的制作[J]. 光学精密工程, 2008,16(8):1396-1402.
SUN Xiaona, ZHOU Hongbo, LI Gang, et al. Fabrication of a flexible three-dimensional neural microelectrode array [J]. Optics and Precision Engineering, 2008,16(8):1396-1402.
ZHOU Hongbo, LI Gang, SUN Xiaona, et al. Integration of Au nanorods with flexible thin-film microelectrode arrays for improved neural interfaces [J]. Journal of Microelectromechanical Systems, 2009,18(1):88-96.
周洪波,李刚,金庆辉,等. 植入式双面柔性神经微电极制作方法的研究 [J]. 微细加工技术, 2007,3(6): 54-59.
ZHOU Hongbo, LI Gang, JIN Qinghui, et al. Study on fabrication method of implantable and flexible double-side microelectrodes for neural applications [J]. Microfabrication Technology, 2007,3(6):54-59.
STIEGLITZ T, BEUTEL H, SCHUETTLER M, et al. Micromachined, polyimide-based devices for flexible neural interfaces [J]. Biomedical Microdevices, 2000,2(4):283-294.
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LAI Jiangnan, SUNDERLAND B, XUE Jianming, et al. Study on hydrophilicity of polymer surfaces improved by plasma treatment [J]. Applied Surface Science, 2006,252(10):3375-3379.
WANG C X, LIU Y, XU H L, et al. Influence of atmospheric pressure plasma treatment time on penetration depth of surface modification into fabric [J]. Applied Surface Science, 2008,254(8):2499-2505.
GURUVENKET S, RAO G M, KOMATH M, et al. Plasma surface modification of polystyrene and polyethylene [J]. Applied Surface Science, 2004,236(1/4):278-284.
GRACE J M, GERENSER L J. Plasma treatment of polymers [J]. Journal of Dispersion Science and Technology, 2003,24(3/4):305-341.
FRANKS W, SCHENKER W, SCHMUTZ P, et al. Impedance characterization and modeling of electrodes for biomedical applications [J]. IEEE Transactions on Biomedical Engineering, 2005,52(7):1295-1302.
DABROWSKI W, GRYBOS P, LITKE A M. A low noise multichannel integrated circuit for recording neuronal signals using microelectrode arrays [J]. Biosensors Bioelectronics, 2004,19(7):749-761.
TiO2光阳极有序微结构的纳米压印工艺.西安交通大学学报, 2009,43(11):90-94.
HIV p24/gp36安培联检芯片.西安交通大学学报, 2009,43(7):115-119.
脑深部刺激电极的结构优化及其模拟分析.西安交通大学学报, 2008,42(12):1537-1540.
铝衬底微等离子体阵列的制作与光电特性测量.西安交通大学学报, 2008,42(8):982-985.
铂碳电极苯/水体系阴极反应规律的研究.西安交通大学学报, 2008,42(8):1040-1043.
Co替代Ni对钛钒基储氢电极合金循环稳定性的影响.西安交通大学学报, 2008,42(5):630-633.
电极几何参数对离子电流影响的试验研究.西安交通大学学报, 2008,42(1):36-40.
氧化锌/银双层膜负反馈阴极电极的制备及性能研究.西安交通大学学报, 2007,41(12):1470-1473.
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