载细胞水凝胶体系中微通道结构对营养物输送能力的影响

黄国友 1; 徐峰 1; 2; 周丽宏 1; 周进雄 1; 陈咏梅 1; 3; 卢天健 1

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载细胞水凝胶体系中微通道结构对营养物输送能力的影响

更新时间：2025-07-09

- 载细胞水凝胶体系中微通道结构对营养物输送能力的影响
- Influence of Microfluidic Channels on Delivery of Nutrient in Cell-Laden Hydrogels
- 西安交通大学学报 2011年45卷第4期页码：115-120
- 作者机构：
  
  西安交通大学生物医学工程与生物力学中心,西安,710049
- 作者简介：
- 基金信息：
  
  : 2010-10-13. 作者简介: 黄国友(1984-),男,博士生;卢天健(联系人),男,教授,博士生导师. 基金项目: 国家自然科学基金资助项目(10825210,10872157);国家“111引智计划”资助项目(B06024);陕西省自然科学基金资助项目(2010JQ1010);西安交通大学校基金资助项目(08143004)
- DOI：
  中图分类号： Q81
- 网络首发：2011-04-10，
  
  纸质出版：2011
- 稿件说明：
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黄国友 1, 徐峰 1, 2, 等. 载细胞水凝胶体系中微通道结构对营养物输送能力的影响[J]. 西安交通大学学报, 2011,45(4):115-120.

Influence of Microfluidic Channels on Delivery of Nutrient in Cell-Laden Hydrogels[J]. 2011, 45(4): 115-120.
黄国友 1, 徐峰 1, 2, 等. 载细胞水凝胶体系中微通道结构对营养物输送能力的影响[J]. 西安交通大学学报, 2011,45(4):115-120. DOI：

Influence of Microfluidic Channels on Delivery of Nutrient in Cell-Laden Hydrogels[J]. 2011, 45(4): 115-120. DOI：

摘要

为了优化载细胞水凝胶中微通道的结构设计

通过数值模拟

系统地研究了孔隙率、微通道数目及排布方式等参数对营养物输送能力的影响.研究结果表明:在给定微通道数目下

微通道尺寸和间距均存在最优值

与此相对应的营养物输送能力最佳; 当孔隙率或微通道数目较大时

微通道排布方式对营养物的输送能力无明显影响.通过参数优化

可以更好地提高微通道的营养物输送能力

尤其是保证远离微通道表面的细胞得到充足的营养物供应

为组织工程化组织中微通道结构的优化设计提供指导.

Abstract

To optimize the structural parameters of microfluidic cell-laden hydrogels embedded with microchannels

a mathematical model is developed to systematically investigate the influence of microchannel size

inter-channel separation

number of channels and their distribution on nutrient transport in cell-laden hydrogels. The simulation results show that there exist the optimal microchannel size and inter-channel separation for enhanced nutrient utilization. While the porosity is fixed

the capability of nutrient transport is improved with the increasing channel number. The distribution of channels exerts slight effect on the nutrient delivery as the number of channels gets beyond 6. In addition

the nutrient transport can be enhanced by adjusting the diffusion properties of hydrogels. The present results provide useful guidance for the experimental design of microfluidic tissue constructs.

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references

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