应用电声脉冲法的细胞膜电特性研究

张跃; 钟力生; 成林; 程湘东; 朱华

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应用电声脉冲法的细胞膜电特性研究

更新时间：2025-07-09

- 应用电声脉冲法的细胞膜电特性研究
- Study of Cell Membrane Charging Properties with Pulsed Electro-Acoustic Method
- 西安交通大学学报 2011年45卷第6期页码：81-84+123
- 作者机构：
  
  西安交通大学电力设备电气绝缘国家重点实验室,西安,710049
- 作者简介：
- 基金信息：
  
  : 2010-11-03. 作者简介: 张跃(1982-),男,博士生;钟力生(联系人),男,教授,博士生导师. 基金项目: 国家重点基础研究发展规划资助项目(2011CB503701)
- DOI：
  中图分类号： TM930.12
- 网络首发：2011-06-10，
  
  纸质出版：2011
- 稿件说明：
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张跃, 钟力生, 成林, 等. 应用电声脉冲法的细胞膜电特性研究[J]. 西安交通大学学报, 2011,45(6):81-84+123.

Study of Cell Membrane Charging Properties with Pulsed Electro-Acoustic Method[J]. 2011, 45(6): 81-84+123.
张跃, 钟力生, 成林, 等. 应用电声脉冲法的细胞膜电特性研究[J]. 西安交通大学学报, 2011,45(6):81-84+123. DOI：

Study of Cell Membrane Charging Properties with Pulsed Electro-Acoustic Method[J]. 2011, 45(6): 81-84+123. DOI：

摘要

首次将电声脉冲法(PEA)应用于研究脉冲电场下生物细胞的电特性

试样采用一种类似“三文治”的结构

可以看作是一种复合介质.利用PEA装置测量多层复合介质试样的一个关键问题在于声波会在界面处发生透射和反射

给测量带来很大的误差.通过对试样模型和声波传播过程的分析

求解出了界面处的声波传输方程.根据传输方程推导出波形修正公式

并编写了波形恢复程序

取得了较理想的结果.文中波形处理方法同样适用于其他复合介质的测量

对于同类问题分析具有一定的参考价值.

Abstract

The pulsed electro-acoustic(PEA)method is firstly used to measure the charging properties of biological cells under a pulsed electric field by means of a sandwich-like model

which can be treated as composite dielectrics. For measuring space charge in the composite dielectrics with PEA method the reflection and absorption of acoustic wave at the interfaces often bring forth a great error. By analyzing and modeling the transmission of acoustic wave in samples

the transmission equations of sound wave at the interface are solved. According to the transmission equations

the modifier formulas are derived and the experimental waveform recovery program is established. The waveform recovery method is also appropriate for the other measurements of composite dielectrics.

关键词

Keywords

references

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崔湘屏,王淑秋,马青.人红细胞对10 kHz～100 MHz 电磁场的介电响应探讨 [J]. 黑龙江医药科学, 2004,27(4):12-14.

CUI Xiangping, WANG Shuqiu, MA Qing. Dielectric response of human erythrocytes in the frequency range of 10 kHz-100 MHz [J]. Heilongjiang Medicine and Pharmacy, 2004,27(4):12-14.

徐传骧,刘辅宜,钟力生,等.工程电介质物理与介电现象 [M].西安: 西安交通大学出版社,2007:137-138.

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BEEBE S J, FOX P M, REC L J,et al. Nanosecond pulsed electric field(ns PEF)effects on cells and tissues: apoptosis introduction and tumor growth inhibition [J]. IEEE Trans Plasma Sci, 2002, 30: 286-292.

FU M, CHEN G, DAVIES A E. Space charge measurements in cables using the PEA method: signal data processing considerations [C]∥IEEE 7th International Conference on Solid Dielectrics. Piscataway, NJ, USA: IEEE, 2001:219-222.

BODEGA R, MORSHUIS P H F. Space charge measurements on multi-dielectrics by means of pusled electroacoustic method [J]. IEEE Trans Electrical Insul, 2006, 13(2): 272-281.

ZHU Yongchang, TU Demin, TAKADA T. Mathematical analysis and interpretation of pulsed electro-acoustic system [C]∥Proceedings of the 6th International Conference on Properties and Applications of Dielectric Materials. Xi'an, China: Xi'an Jiaotong University, 2000:63-66.

WADAMORI M, FUKUMA M. Proposal of numerical analysis model of acoustic wave propagation and generation on PEA method [C]∥Proceedings of the 7th International Conference on Properties and Applications of Dielectric Materials. Nagoya, Japan: [n.s.], 2003:863-866.

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