可降解聚合物溶胀性能对给药系统释药效果的影响

高扬; 王小鹏; 陈天宁

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可降解聚合物溶胀性能对给药系统释药效果的影响

更新时间：2025-07-09

- 可降解聚合物溶胀性能对给药系统释药效果的影响
- Effect of Degradable Polymer Swelling Property on Release Performance of Controlled Drug Delivery System
- 西安交通大学学报 2012年46卷第1期页码：114-119
- 作者机构：
  
  西安交通大学机械工程学院,西安,710049
- 作者简介：
- 基金信息：
  
  : 2011-05-31. 作者简介: 高扬(1983-),女,博士生;陈天宁(通信作者),男,教授,博士生导师. 基金项目: 国家高技术研究发展计划资助项目(2006AA04Z330);国家自然科学基金资助项目(50705074);中央高校基本科研业务费专项资金资助项目
- DOI：
  中图分类号： TB324
- 网络首发：2012-01-10，
  
  纸质出版：2012
- 稿件说明：
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高扬, 王小鹏, 陈天宁. 可降解聚合物溶胀性能对给药系统释药效果的影响[J]. 西安交通大学学报, 2012,46(1):114-119.

Effect of Degradable Polymer Swelling Property on Release Performance of Controlled Drug Delivery System[J]. 2012, 46(1): 114-119.
高扬, 王小鹏, 陈天宁. 可降解聚合物溶胀性能对给药系统释药效果的影响[J]. 西安交通大学学报, 2012,46(1):114-119. DOI：

Effect of Degradable Polymer Swelling Property on Release Performance of Controlled Drug Delivery System[J]. 2012, 46(1): 114-119. DOI：

摘要

针对以乳酸-羟基乙酸共聚物(PLGA)作为药物载体的新型贮库式微孔结构缓控释给药系统

为量化PLGA溶胀特性对释药效果的影响

在模拟体液环境下

以具有不同单体质量比的PLGA膜片上的微孔为研究对象

对PLGA在降解过程中的溶胀现象进行了实验研究

得到单体质量比为50:50的PLGA的微孔径向溶胀速率约为2.7×10

-10

m/s

质量比为65:35的 PLGA的微孔径向溶胀速率约为6.6×10

-11

m/s.以单体质量比为50:50的PLGA为例

将实验得到的微孔溶胀速率作为边界条件

对考虑PLGA溶胀作用前、后的微孔给药系统释药过程进行了有限元模拟

结果表明:聚合物溶胀使给药系统释药时间从无溶胀时的16 d延长到33 d; 不考虑溶胀时

PLGA基体仅起承载药物的作用

而考虑溶胀后

微孔和PLGA基体共同承担药物释放功能

其中近40%的药物通过微孔释放

近60%的药物通过聚合物载体释放; 给药系统在整个释药过程中累积释药比率线性度较好.

Abstract

To quantitate the effect of poly(lactic-co-glycolic acid)(PLGA)swelling property on the drug release performance of the novel microholes controlled drug delivery system(MCDDS)

swelling experiments were conducted with different monomer ratios of PLGA

and the results show that the changing rates of microholes caused by the PLGA swelling reach 2.7×10

-10

m/s of 50:50 PLGA and 6.6×10

-11

m/s of 65:35 PLGA. Taking 50:50 PLGA for example

the release processes of MCDDS were simulated by the finite element method with swelling rate as the boundary condition. Results show that the release period of MCDDS extends from 16 days without polymer swelling to 33 days as the PLGA swelling is considered; the m

atrix of PLGA only serves as a carrier without polymer swelling

whereas the polymer matrix and the microholes both play important roles in drug releasing when the swelling is considered

nearly 40% drug releases through microholes and 60% drug releases through polymer matrix. The cumulative released drug in the whole releasing process maintains approximate linearity.

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Keywords

references

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