Advances in Research and Application of Boron Neutron Capture Therapy for Cancer Treatment

WANG Sheng; LI Zhifeng; LI Haipeng; YANG Shanghui; XIE Yupeng; LI Jie

doi:10.7652/xjtuxb202604011

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Advances in Research and Application of Boron Neutron Capture Therapy for Cancer Treatment

Special Topic Outstanding Achievements in Natural Sciences of Xi'an Jiaotong University | 更新时间：2026-04-10

- Advances in Research and Application of Boron Neutron Capture Therapy for Cancer Treatment
- Journal of Xi'an Jiaotong University Vol. 60, Issue 4, Pages: 140-150(2026)
- 作者机构：
  
  西安交通大学国家医学攻关产教融合创新平台（中心），710049，西安
  华硼中子科技（杭州）有限公司，310000，杭州
- 作者简介：
- 基金信息：
- DOI：10.7652/xjtuxb202604011
  CLC： TL99
- Received：26 September 2025，
  
  Online First：15 October 2025，
  
  Published：10 April 2026
- 稿件说明：
移动端阅览
WANG Sheng, LI Zhifeng, LI Haipeng, et al. Advances in Research and Application of Boron Neutron Capture Therapy for Cancer Treatment[J]. Journal of Xi'an Jiaotong University, 2026, 60(4): 140-150.
DOI：

WANG Sheng, LI Zhifeng, LI Haipeng, et al. Advances in Research and Application of Boron Neutron Capture Therapy for Cancer Treatment[J]. Journal of Xi'an Jiaotong University, 2026, 60(4): 140-150. DOI： 10.7652/xjtuxb202604011.

摘要

硼中子俘获治疗（BNCT）作为一种二元靶向放疗技术，以“高选择性、高效杀伤、低正常组织损伤”的特点受到广泛关注。随着紧凑型加速器中子源技术的成熟发展，BNCT正逐步摆脱对核反应堆的依赖，向临床实用化、装置小型化方向快速迈进，同时也对系统性能提出了更高要求。基于加速器的BNCT（AB-BNCT）技术高度依赖于加速器、中子转化靶以及个体化治疗计划系统三大核心子系统的协同发展。围绕上述子系统，结合西安交通大学硼中子俘获治疗技术团队的具体产品研发案例，综述了AB-BNCT系统的研究与应用进展。在高性能加速器研发方面，着重分析了射频直线加速器、回旋加速器和静电/串列加速器的特性以及在BNCT中的应用情况。在中子转换靶设计方面，重点探讨了靶系统的氢鼓泡问题和散热问题，并总结了相应的解决方案。在个体化治疗计划系统的开发方面，归纳了BNCT计划系统的研究与应用现状，全面介绍了西安交通大学硼中子俘获治疗技术团队在个性化体素模型建立与剂量验证等问题上提出的全流程自主化解决方案。展望未来，BNCT技术将朝着紧凑型、标准化及适应症拓展等方向持续深化，其发展仍需加速器物理、核技术、医学物理、药学及临床医学等多学科更紧密的交叉与融合。

Abstract

Boron neutron capture therapy（BNCT）is a binary targeted radiotherapy technology that has garnered widespread attention due to its characteristics of high selectivity，efficient tumor cell killing，and low damage to normal tissues.With the mature development of compact accelerator-based neutron source technology，BNCT is progressively reducing its dependence on nuclear reactors and advancing rapidly towards clinical utility and device miniaturization，while simultaneously imposing higher requirements on system performance.Accelerator-based BNCT（AB-BNCT）technology relies heavily on the synergistic development of three core subsystems：the accelerator，the neutron conversion target，and the individualized treatment planning system. Centering on these subsystems and incorporating specific product development cases from the BNCT research team at Xi'an Jiaotong University，this paper reviews the research and application advances in AB-BNCT systems.Regarding the development of high-performance accelerators，the characteristics and application status in BNCT of radio-frequency linear accelerators，cyclotrons，and electrostatic/tandem accelerators are analyzed.In terms of neutron conversion target design，key issues such as hydrogen blistering and thermal dissipation in the target system are discussed，and corresponding solutions are summarized. Concerning the development of individualized treatment planning systems，the current research and application status of BNCT planning systems are outlined，and a comprehensive，fully autonomous solution proposed by the Xi'an Jiaotong University BNCT research team for personalized voxel model establishment and dose verification is introduced.Looking ahead，BNCT technology will continue to deepen in the directions of compactness，standardization，and the expansion of treatment indications.Its further development will require even closer interdisciplinary integration among accelerator physics，nuclear technology，medical physics，pharmaceuticals，and clinical medicine.

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