Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair

ZHAO Yue; ZHAO Yinan; XU Yan; CHEN Yutong; YIN Zhitao; CHAO Jian; ZHOU Jianping

doi:10.7652/xjtuxb202506009

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Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair

Special Topic　Material Performance Optimization | 更新时间：2025-08-26

- Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair
- Journal of Xi’an Jiaotong University Vol. 59, Issue 6, Pages: 82-92(2025)
- 作者机构：
  
  1.新疆大学机械工程学院， 830047，乌鲁木齐
  2.华中科技大学材料科与技术系， 430074，武汉
- 作者简介：
- 基金信息：
- DOI：10.7652/xjtuxb202506009
  CLC： TH114
- Received：18 November 2024，
  
  Online First：22 January 2025，
  
  Published：10 June 2025
- 稿件说明：
移动端阅览
ZHAO Yue, ZHAO Yinan, XU Yan, et al. Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair[J]. Journal of Xi’an Jiaotong University, 2025, 59(6): 82-92.
DOI：

ZHAO Yue, ZHAO Yinan, XU Yan, et al. Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair[J]. Journal of Xi’an Jiaotong University, 2025, 59(6): 82-92. DOI： 10.7652/xjtuxb202506009.

摘要

针对骨修复应用中硅酸钙存在机械强度不足的问题，通过化学沉淀法，制备了一种掺镁硅酸钙陶瓷材料，并构建了兼具良好机械强度和生物相容性的骨修复支架。首先，向硅酸钙粉体中引入不同质量分数的镁粉末颗粒，并改变镁与硅酸钙粉体的掺杂比例，通过球磨、脱脂烧结等工艺制备掺镁硅酸钙陶瓷材料；然后，采用3D打印数字光处理技术(DLP)，打印内、外直径分别为2.8 mm和5 mm，高度为6 mm的空心圆柱，构建用于骨修复的骨支架；最后，采用力学实验、CCK-8细胞增殖检测和碱性磷酸酶检测(ALP)，探究镁掺杂量对可降解生物陶瓷抗压强度和生物相容性的影响规律。实验结果表明：所构建掺镁硅酸钙支架的弹性模量为94～110 MPa，是硅酸钙支架弹性模量(33 MPa)的2.85～3.33倍；掺镁质量分数分别为5%和10%的掺镁硅酸钙支架细胞存活率为94%～97%，具有良好的生物相容性；掺镁质量分数分别为15%和20%的掺镁硅酸钙支架细胞存活率均低于70%，不利于细胞增殖；当掺镁质量分数为10%、烧结温度为1 000 ℃时，掺镁硅酸钙支架兼具最佳的力学性能和生物相容性。

Abstract

In response to the insufficient mechanical strength of calcium silicate in bone repair applications

a magnesium-doped calcium silicate ceramic material was prepared using a chemical precipitation method

and a bone repair scaffold with both excellent mechanical strength and biocompatibility was constructed. First

magnesium powder particles with different mass fractions were introduced into the calcium silicate powder

and the doping ratio of magnesium to calcium silicate powder was adjusted. Magnesium-doped calcium silicate ceramic materials were prepared by ball milling and de-binding sintering and other processes. Then

a 3D printing digital light processing (DLP) technique was used to print hollow cylinders with inner and outer diameters of 2.8 mm and 5 mm respectively

and a height of 6 mm

to construct bone scaffolds for bone repair. Finally

mechanical tests

CCK-8 cell proliferation assays

and alkaline phosphatase (ALP) tests were conducted to explore the effects of magnesium doping on the compressive strength and biocompatibility of biodegradable bioceramics. The experimental results showed that the elastic modulus of the magnesium-doped calcium silicate scaffold ranged from 94 MPa to 110 MPa

which is 2.85 to 3.33 times that of the calcium silicate scaffold (33 MPa). The cell viability of magnesium-doped calcium silicate scaffolds with mass fractions of 5% and 10% ranged from 94% to 97%

indicating good biocompatibility. In contrast

scaffolds with magnesium mass fractions of 15% and 20% exhibited cell viability below 70%

which is unfavorable for cell proliferation. With a magnesium doping level of 10% and a sintering temperature of 1 000 ℃

the magnesium-doped calcium silicate scaffold achieved the optimal combination of mechanical properties and biocompatibility.

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references

陈若梦 , 伍言龙 , 赵广宾 . 聚己内酯增强β-磷酸三钙复合支架的制备及力学性能 [J ] . 西安交通大学学报 , 2024 , 58 ( 3 ): 129 - 136 .

CHEN Ruomeng , WU Yanlong , ZHAO Guangbin . Preparation and mechanical properties of polycaprolactone enhancement β-tricalcium phosphate composite scaffold [J ] . Journal of Xi'an Jiaotong University , 2024 , 58 ( 3 ): 129 - 136 .

李腾飞 , 伍言龙 , 赵广宾 , 等 . 多孔硅酸钙/明胶复合支架制备工艺及力学性能研究 [J ] . 西安交通大学学报 , 2021 , 55 ( 4 ): 172 - 180 .

LI Tengfei , WU Yanlong , ZHAO Guangbin , et al . Fabrication process and mechanical performance of porous calcium silicate/gelatin composite scaffold [J ] . Journal of Xi'an Jiaotong University , 2021 , 55 ( 4 ): 172 - 180 .

LU Teliang , MIAO Yali , WU Tingting , et al . Effects of Zn/Sr co-substitution on the physicochemical properties and cellular responses of wollastonite [J ] . Ceramics International , 2024 , 50 ( 10 ): 17214 - 17227 .

LIANG Caixia , LU Teliang , HE Fupo , et al . In vitro biomineralization behaviors and mechanism as well as cell responses of calcium silicate ceramics [J ] . Journal of Materials Science , 2022 , 57 ( 31 ): 14655 - 14667 .

GRANEL H , BOSSARD C , NUCKE L , et al . Optimized bioactive glass: the quest for the bony graft [J ] . Advanced Healthcare Materials , 2019 , 8 ( 11 ): 1801542 .

SCHRÖTER L , KAISER F , STEIN S , et al . Biological and mechanical performance and degradation characteristics of calcium phosphate cements in large animals and humans [J ] . Acta Biomaterialia , 2020 , 117 : 1 - 20 .

ZHOU Panyu , XIA Demeng , NI Zhexin , et al . Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M [J ] . Bioactive Materials , 2021 , 6 ( 3 ): 810 - 822 .

ZENEBE C G . A review on the role of wollastonite biomaterial in bone tissue engineering [J ] . BioMed Research International , 2022 , 2022 : 4996530 .

VUKOMANOVIC M , GAZVODA L , ANICIC N , et al . Multi-doped apatite: strontium, magnesium, gallium and zinc ions synergistically affect osteogenic stimulation in human mesenchymal cells important for bone tissue engineering [J ] . Biomaterials Advances , 2022 , 140 : 213051 .

QIAO Xinrui , YANG Jie , SHANG Yuli , et al . Magnesium-doped nanostructured titanium surface modulates macrophage-mediated inflammatory response for ameliorative osseointegration [J ] . International Journal of Nanomedicine , 2020 , 15 : 7185 - 7198 .

NAMDAR A , SALAHINEJAD E . Advances in ion-doping of Ca-Mg silicate bioceramics for bone tissue engineering [J ] . Coordination Chemistry Reviews , 2023 , 478 : 215001 .

HE Fupo , YUAN Xinyuan , LU Teliang , et al . Preparation and characterization of novel lithium magnesium phosphate bioceramic scaffolds facilitating bone generation [J ] . Journal of Materials Chemistry B , 2022 , 10 ( 21 ): 4040 - 4047 .

PREDOI D , ICONARU S L , PREDOI M V , et al . Synthesis, characterization, and antimicrobial activity of magnesium-doped hydroxyapatite suspensions [J ] . Nanomaterials , 2019 , 9 ( 9 ): 1295 .

LIN Y H , LEE A K X , HO C C , et al . The effects of a 3D-printed magnesium-/strontium-doped calcium silicate scaffold on regulation of bone regeneration via dual-stimulation of the AKT and WNT signaling pathways [J ] . Biomaterials Advances , 2022 , 133 : 112660 .

DU Zhiyun , LENG Huijie , GUO Liying , et al . Calcium silicate scaffolds promoting bone regeneration via the doping of Mg 2+ or Mn 2+ ion [J ] . Composites: Part B Engineering , 2020 , 190 : 107937 .

WANG Xinhui , LIU Jinghang , DONG Ruihai , et al . High-precision digital light processing (DLP) printing of microstructures for microfluidics applications based on a machine learning approach [J ] . Virtual and Physical Prototyping , 2024 , 19 ( 1 ): e2318774 .

WANG Xinhui , LIU Jinghang , ZHANG Yang , et al . Advances in precision microfabrication through digital light processing: system development, material and applications [J ] . Virtual and Physical Prototyping , 2023 , 18 ( 1 ): e2248101 .

FENG Pei , ZHAO Rongyang , TANG Weiming , et al . Structural and functional adaptive artificial bone: materials, fabrications, and properties [J ] . Advanced Functional Materials , 2023 , 33 ( 23 ): 2214726 .

CHEN Annan , WANG Wanying , MAO Zhengyi , et al . Multimaterial 3D and 4D bioprinting of heterogenous constructs for tissue engineering [J ] . Advanced Materials , 2024 , 36 ( 34 ): 2307686 .

WU Yonghao , CAO Quanle , WANG Yilei , et al . Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration [J ] . Materials & Design , 2023 , 233 : 112230 .

WANG Yue , CHEN Shangsi , LIANG Haowen , et al . Digital light processing (DLP) of nano biphasic calcium phosphate bioceramic for making bone tissue engineering scaffolds [J ] . Ceramics International , 2022 , 48 ( 19, Part A ): 27681 - 27692 .

GU Quanchao , WANG Honglei , GAO Wenjie , et al . Preparation of large-size alumina ceramic parts by DLP 3D printing using high-solid-loading paste and optimizing the debinding process [J ] . Ceramics International , 2023 , 49 ( 17 ): 28801 - 28812 .

DE LISI M , CARERI F , ATTIA U M , et al . Effect of different additives and sintering regimes on the optical properties of DLP printed translucent alumina [J ] . Ceramics International , 2024 , 50 ( 14 ): 26065 - 26076 .

杨蒙蒙 , 伍言龙 , 许燕 , 等 . 生物玻璃陶瓷骨支架的光固化成形工艺与过固化研究 [J ] . 西安交通大学学报 , 2022 , 56 ( 9 ): 151 - 159 .

YANG Mengmeng , WU Yanlong , XU Yan , et al . Forming process and overcure of bioglass ceramic bone scaffold by photocuring technology [J ] . Journal of Xi'an Jiaotong University , 2022 , 56 ( 9 ): 151 - 159 .

刘永财 , 伍言龙 , 刘亚雄 . 熔融挤出增材制造的镁/聚己内酯复合材料的体外降解特性 [J ] . 高分子材料科学与工程 , 2021 , 37 ( 11 ): 125 - 133 .

LIU Yongcai , WU Yanlong , LIU Yaxiong . Degradation properties of Magnesium-Polycaprolactone composite by fused extrusion additive manufacturing process [J ] . Polymer Materials Science & Engineering , 2021 , 37 ( 11 ): 125 - 133 .

SHAO Huifeng , JING Zhuoluo , XIA Pengcheng , et al . 3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property [J ] . Materials & Design , 2023 , 225 : 111464 .

杨蒙蒙 , 伍言龙 , 陈旭 , 等 . 生物玻璃陶瓷骨支架光固化3D打印及降解性能 [J ] . 硅酸盐通报 , 2023 , 42 ( 1 ): 267 - 275 .

YANG Mengmeng , WU Yanlong , CHEN Xu , et al . Photocuring 3 D printing and degradation performance of bioglass ceramic bone scaffold [J ] . Bulletin of the Chinese Ceramic Society , 2023 , 42 ( 1 ): 267 - 275 .

FU Zeyu , LI Dejian , CUI Jinjie , et al . Promoting bone regeneration via bioactive calcium silicate nanowires reinforced poly ( ε -caprolactone) electrospun fibrous membranes [J ] . Materials & Design , 2023 , 226 : 111671 .

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