Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine

LI Dong; LIN Zhanle; FENG Jing; SHI Jinwen; SUN Chengzhen; ZHANG Hao; YU Zejia; CHEN Bin; WANG Guoxiang; ZHOU Zhifu; YAO Liang; ZHENG Yuping; WANG Huiyuan; GAO Ning

doi:10.7652/xjtuxb202505004

您当前的位置：

首页 >

文章列表页 >

Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine

Special Topic　Medical-Engineering Intersection and Human-Computer Interaction | 更新时间：2025-08-26

- Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine
- Journal of Xi’an Jiaotong University Vol. 59, Issue 5, Pages: 30-43(2025)
- 作者机构：
  
  1.西安交通大学动力工程多相流国家重点实验室， 710049，西安
  2.阿克伦大学机械工程系， 44325，美国阿克伦
  3.西安交通大学第二附属医院， 710004，西安
  4.西安交通大学第一附属医院， 710061，西安
- 作者简介：
- 基金信息：
- DOI：10.7652/xjtuxb202505004
  CLC： R318
- Received：28 October 2024，
  
  Online First：13 January 2025，
  
  Published：10 May 2025
- 稿件说明：
移动端阅览
LI Dong, LIN Zhanle, FENG Jing, et al. Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine[J]. Journal of Xi’an Jiaotong University, 2025, 59(5): 30-43.
DOI：

LI Dong, LIN Zhanle, FENG Jing, et al. Review on the Research Progress of Micro-Nano Materials in Hydrogen Molecular Medicine[J]. Journal of Xi’an Jiaotong University, 2025, 59(5): 30-43. DOI： 10.7652/xjtuxb202505004.

摘要

自2007年首次发现氢分子具有选择性抗氧化特性以来，氢分子迅速成为现代医学研究的热点，多项研究已证实其在多种动物模型和人类疾病中发挥着积极作用。针对传统氢分子给药（如吸入氢气、饮用富氢水和注射氢盐水等）存在的利用率低、释放难以控制和靶向性不足等问题，微纳材料给出了新的解决方案。从微纳材料的释氢原理出发，综述了吸附载氢与原位释氢两种主要策略，以及它们在协同治疗中的前沿应用。吸附载氢依靠物理或化学吸附储存氢气，通过温度、压力等外部调控实现释放；原位释氢则利用化学反应、光热催化或生物手段在特定病理环境中生成氢气，可通过内源响应或外源调控达到更高的靶向性和可控性。以微纳材料为媒介，结合氢分子的抗炎、抗肿瘤等功能，氢分子还可通过与化疗药物、光热疗法及光动力疗法的协同作用，显著增强对肿瘤疾病的治疗效果。同时，还总结了当前面临的生物安全性、靶向性及规模化生产等挑战，并提出未来需通过设计智能响应材料及氢分子多模式协同治疗相结合，进一步提高治疗效果与精准性，为后续基于微纳材料的氢分子医学提供了指导。

Abstract

Since the selective antioxidant properties of hydrogen molecules were first discovered in 2007

hydrogen molecules has rapidly become a research focus in modern medicine. In numerous studies

its positive effects in various animal models and human diseases have been demonstrated. In response to the issues of low utilization

difficulty in controlling release

and insufficient targeting associated with traditional hydrogen molecule delivery methods (such as inhaling hydrogen gas

drinking hydrogen-rich water

and injecting hydrogen saline)

micro-nano materials offer new solutions. Starting from the hydrogen release mechanism of micro-nano materials

two main strategies are discussed in this review: hydrogen adsorption and in situ hydrogen release

as well as their cutting-edge applications in synergistic therapies. Hydrogen adsorption relies on physical or chemical adsorption for hydrogen storage

with release controlled by external stimuli such as temperature and pressure. In contrast

in situ hydrogen release utilizes chemical reactions

photothermal catalysis

or biological mechanisms to generate hydrogen in specific pathological environments

achieving higher targeting and controllability through endogenous responses or exogenous regulation. Utilizing micro-nano materials as a medium

and combining the anti-inflammatory and anti-tumor functions of hydrogen molecules

hydrogen molecules can significantly enhance the therapeutic effect on tumor diseases through synergistic interactions with chemotherapy drugs

photothermal therapy

and photodynamic therapy. In this review

current challenges

including issues of biosafety

targeting

and scalable production are also summarized

and future directions such as the design of smart responsive materials combined with multimodal synergistic therapy using hydrogen molecules are proposed

to further improve therapeutic precision and efficacy. This provides guidance for subsequent advancements in hydrogen molecular medicine based on micro-nano materials.

关键词

Keywords

references

OHSAWA I , ISHIKAWA M , TAKAHASHI K , et al . Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals [J ] . Nature Medicine , 2007 , 13 ( 6 ): 688 - 694 .

OHTA S . Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications [J ] . Methods in Enzymology , 2015 , 555 : 289 - 317 .

SETSUKINAI K I , URANO Y , KAKINUMA K , et al . Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species [J ] . Journal of Biological Chemistry , 2003 , 278 ( 5 ): 3170 - 3175 .

IGARASHI T , OHSAWA I , KOBAYASHI M , et al . Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery [J ] . Scientific Reports , 2016 , 6 ( 1 ): 31190 .

CHENG Danyu , LONG Jiangang , ZHAO Lin , et al . Hydrogen: a rising star in gas medicine as a mitochondria-targeting nutrient via activating Keap1-Nrf2 antioxidant system [J ] . Antioxidants , 2023 , 12 ( 12 ): 2062 .

ZHANG Hongqiao , DAVIES K J A , FORMAN H J . Oxidative stress response and Nrf2 signaling in aging [J ] . Free Radical Biology and Medicine , 2015 , 88 ( Part B ): 314 - 336 .

GHARIB B , HANNA S , ABDALLAHI O M , et al . Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation [J ] . Comptes Rendus de l'Académie des Sciences: Series Ⅲ Sciences de la Vie , 2001 , 324 ( 8 ): 719 - 724 .

YU Jianhua , ZHANG Weiguang , ZHANG Rongguo , et al . Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression [J ] . Toxicology Letters , 2015 , 238 ( 3 ): 11 - 19 .

XIE Keliang , ZHANG Yang , WANG Yaoqi , et al . Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation [J ] . Inflammation Research , 2020 , 69 ( 7 ): 697 - 710 .

YU Yang , YANG Yongyan , YANG Man , et al . Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway [J ] . International Immunopharmacology , 2019 , 69 : 11 - 18 .

CAI Wenwen , ZHANG Minghua , YU Yongsheng , et al . Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast [J ] . Molecular and Cellular Biochemistry , 2013 , 373 ( 1/2 ): 1 - 9 .

JIN Zhaokui , ZHAO Penghe , GONG Wanjun , et al . Fe-porphyrin: a redox-related biosensor of hydrogen molecule [J ] . Nano Research , 2023 , 16 ( 2 ): 2020 - 2025 .

陶鸽如 , 秦树存 . 氢生物医学效应在疏解自由基氧化应激的分子机制 [J ] . 生物技术进展 , 2022 , 12 ( 4 ): 490 - 496 .

TAO Geru , QIN Shucun . Molecular mechanism of hydrogen biomedicine in relieving free radical oxidative stress [J ] . Current Biotechnology , 2022 , 12 ( 4 ): 490 - 496 .

赵敏 , 秦树存 . 氢气生物医学效应的发现、研究与应用 [J ] . 山东第一医科大学(山东省医学科学院)学报 , 2021 , 42 ( 5 ): 339 - 346 .

ZHAO Min , QIN Shucun . Discovery, research and application of hydrogen biomedical effects [J ] . Journal of Shandong First Medical University & Shandong Academy of Medical Sciences , 2021 , 42 ( 5 ): 339 - 346 .

江雪 , 刘伯言 , 吴逢霖 , 等 . 氢分子应用于疾病治疗的临床研究进展 [J ] . 山东第一医科大学(山东省医学科学院)学报 , 2023 , 44 ( 7 ): 552 - 560 .

JIANG Xue , LIU Boyan , WU Fenglin , et al . Progress in clinical research on the use of hydrogen molecules in the treatment of diseases [J ] . Journal of Shandong First Medical University & Shandong Academy of Medical Sciences , 2023 , 44 ( 7 ): 552 - 560 .

SHI Qiao , LIAO Kangshu , ZHAO Kailiang , et al . Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway [J ] . Mediators of Inflammation , 2015 , 2015 ( 1 ): 685043 .

SHAO Anwen , WU Haijian , HONG Yuan , et al . Hydrogen-rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response: possible involvement of NF-κB pathway and NLRP3 inflammasome [J ] . Molecular Neurobiology , 2016 , 53 ( 5 ): 3462 - 3476 .

QIN Zhexue , YU Pan , QIAN Dehui , et al . Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway [J ] . Atherosclerosis , 2012 , 220 ( 2 ): 343 - 350 .

ZHANG Guangchao , LI Zhe , MENG Chao , et al . The anti-inflammatory effect of hydrogen on lung transplantation model of pulmonary microvascular endothelial cells during cold storage period [J ] . Transplantation , 2018 , 102 ( 8 ): 1253 - 1261 .

CHEN Meihong , ZHANG Jie , CHEN Yun , et al . Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses [J ] . Scientific Reports , 2018 , 8 ( 1 ): 8004 .

RADYUK S N . Mechanisms underlying the biological effects of molecular hydrogen [J ] . Current Pharmaceutical Design , 2021 , 27 ( 5 ): 626 - 735 .

ONO H , NISHIJIMA Y , ADACHI N , et al . A basic study on molecular hydrogen (H 2 ) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H 2 level [J ] . Medical Gas Research , 2012 , 2 ( 1 ): 21 .

GUAN Weijie , WEI Chunhua , CHEN Ailan , et al . Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial [J ] . Journal of Thoracic Disease , 2020 , 12 ( 6 ): 3448 - 3452 .

ZENG Yingying , GUAN Weijie , WANG Kai , et al . Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched case-control study [J ] . BMC Infectious Diseases , 2023 , 23 ( 1 ): 440 .

LIU Xiaoyu , MA Cuiqing , WANG Xiaoyu , et al . Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model [J ] . International Journal of Chronic Obstructive Pulmonary Disease , 2017 , 12 : 1309 - 1324 .

ZHENG Zeguang , SUN Wuzhuang , HU Jieying , et al . Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial [J ] . Respiratory Research , 2021 , 22 ( 1 ): 149 .

HUANG Peikai , WEI Shushan , HUANG Weihua , et al . Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model [J ] . International Immunopharmacology , 2019 , 74 : 105646 .

LEBARON T W , LAHER I , KURA B , et al . Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes 1 [J ] . Canadian Journal of Physiology and Pharmacology , 2019 , 97 ( 9 ): 797 - 807 .

赵云来 , 宋国华 , 程岳雷 , 等 . 地塞米松联合吸入高浓度氢气对百草枯中毒大鼠的治疗作用 [C ] // 2016中国中毒救治首都论坛暨第八届全国中毒及危重症救治学术会议论文集 . 北京 : 中国毒理学会 . 2016 : 163 - 169 .

KAJIYA M , SATO K , SILVA M J B , et al . Hydrogen from intestinal bacteria is protective for concanavalin A-induced hepatitis [J ] . Biochemical and Biophysical Research Communications , 2009 , 386 ( 2 ): 316 - 321 .

AZUMA T , YAMANE M , EKUNI D , et al . Drinking hydrogen-rich water has additive effects on non-surgical periodontal treatment of improving periodontitis: a pilot study [J ] . Antioxidants , 2015 , 4 ( 3 ): 513 - 522 .

TAMAKI N , ORIHUELA-CAMPOS R C , FUKUI M , et al . Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model [J ] . Oxidative Medicine and Cellular Longevity , 2016 , 2016 ( 1 ): 5679040 .

QIAN Liren , SHEN Jianliang , CHUAI Yunhai , et al . Hydrogen as a new class of radioprotective agent [J ] . International Journal of Biological Sciences , 2013 , 9 ( 9 ): 887 - 894 .

TOMOFUJI T , KAWABATA Y , KASUYAMA K , et al . Effects of hydrogen-rich water on aging periodontal tissues in rats [J ] . Scientific Reports , 2014 , 4 ( 1 ): 5534 .

ZHANG Yi , SU Wenjun , CHEN Ying , et al . Effects of hydrogen-rich water on depressive-like behavior in mice [J ] . Scientific Reports , 2016 , 6 ( 1 ): 23742 .

杨建鸿 , 刘伯言 , 陈军 , 等 . 纳米气泡氢水处理对咪喹莫特诱导银屑病小鼠模型的影响 [J ] . 生物技术进展 , 2024 , 14 ( 4 ): 676 - 684 .

YANG Jianhong , LIU Boyan , CHEN Jun , et al . Effects of pre-treatment of nanobubble hydrogen water on the mouse psoriasis induction by imiquimod [J ] . Current Biotechnology , 2024 , 14 ( 4 ): 676 - 684 .

LIU Fangting , XU Shengming , XIANG Zhenghua , et al . Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats [J ] . CNS Neuroscience & Therapeutics , 2014 , 20 ( 8 ): 778 - 786 .

LI Guomin , JI Muhuo , SUN Xuejun , et al . Effects of hydrogen-rich saline treatment on polymicrobial sepsis [J ] . Journal of Surgical Research , 2013 , 181 ( 2 ): 279 - 286 .

SUN Qiang , CAI Jianmei , LIU Shulin , et al . Hydrogen-rich saline provides protection against hyperoxic lung injury [J ] . Journal of Surgical Research , 2011 , 165 ( 1 ): e43 - e49 .

ONO H , NISHIJIMA Y , ADACHI N , et al . Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, edaravone and hydrogen, as compared to edaravone alone: a non-controlled study [J ] . Medical Gas Research , 2011 , 1 ( 1 ): 12 .

李悦娴 , 秦树存 , 张锦 . 富氢水对小鼠脓毒症胰腺损伤的改善作用 [J ] . 天津医药 , 2021 , 49 ( 8 ): 808 - 812 .

LI Yuexian , QIN Shucun , ZHANG Jin . The effect of hydrogen-rich saline on pancreatic injury in septic mice [J ] . Tianjin Medical Journal , 2021 , 49 ( 8 ): 808 - 812 .

ZHOU Gaoxin , GOSHI E , HE Qianjun . Micro/nanomaterials-augmented hydrogen therapy [J ] . Advanced Healthcare Materials , 2019 , 8 ( 16 ): 1900463 .

LOCHAN R C , HEAD-GORDON M . Computational studies of molecular hydrogen binding affinities: the role of dispersion forces, electrostatics, and orbital interactions [J ] . Physical Chemistry Chemical Physics , 2006 , 8 ( 12 ): 1357 - 1370 .

SCHMITZ B , MÜLLER U , TRUKHAN N , et al . Heat of adsorption for hydrogen in microporous high-surface-area materials [J ] . ChemPhysChem , 2008 , 9 ( 15 ): 2181 - 2184 .

原野 , 王明 , 周云琪 , 等 . 金属有机框架孔径调控进展 [J ] . 化工学报 , 2020 , 71 ( 2 ): 429 - 450 .

YUAN Ye , WANG Ming , ZHOU Yunqi , et al . Progress in pore size regulation of metal-organic frameworks [J ] . CIESC Journal , 2020 , 71 ( 2 ): 429 - 450 .

RÖNNEBRO E C E , MAJZOUB E H . Recent advances in metal hydrides for clean energy applications [J ] . MRS Bulletin , 2013 , 38 ( 6 ): 452 - 458 .

ZHAO Penghe , JIN Zhaokui , CHEN Qian , et al . Local generation of hydrogen for enhanced photothermal therapy [J ] . Nature Communications , 2018 , 9 ( 1 ): 4241 .

ZHOU Gaoxin , WANG Yingshuai , JIN Zhaokui , et al . Porphyrin-palladium hydride MOF nanoparticles for tumor-targeting photoacoustic imaging-guided hydrogenothermal cancer therapy [J ] . Nanoscale Horizons , 2019 , 4 ( 5 ): 1185 - 1193 .

KONG Lei , CHEN Chuanrui , MOU Fangzhi , et al . Magnesium particles coated with mesoporous nanoshells as sustainable therapeutic-hydrogen suppliers to scavenge continuously generated hydroxyl radicals in long term [J ] . Particle & Particle Systems Characterization , 2019 , 36 ( 2 ): 1800424 .

WAN Weilin , LIN Y J , SHIH P C , et al . An in situ depot for continuous evolution of gaseous H 2 mediated by a magnesium passivation/activation cycle for treating osteoarthritis [J ] . Angewandte Chemie International Edition , 2018 , 57 ( 31 ): 9875 - 9879 .

ZHANG Wenjing , ZENG Lingting , YU Huan , et al . Injectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis [J ] . Acta Biomaterialia , 2023 , 158 : 163 - 177 .

DAMAGHI M , WOJTKOWIAK J W , GILLIES R J . pH sensing and regulation in cancer [J ] . Frontiers in Physiology , 2013 , 4 : 370 .

YANG Tian , JIN Zhaokui , WANG Zhihao , et al . Intratumoral high-payload delivery and acid-responsive release of H 2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine [J ] . Applied Materials Today , 2018 , 11 : 136 - 143 .

CAO Lin , HUANG Tianqiao , CHEN Xiaohong , et al . Uncovering the interplay between pH receptors and immune cells: potential drug targets (review) [J ] . Oncology Reports , 2021 , 46 ( 4 ): 228 .

JI Yucheng , HU Yuwei , FENG Yubo , et al . Mitochondrial ‘birth-death’ coordinator: an intelligent hydrogen nanogenerator to enhance intervertebral disc regeneration [J ] . Biomaterials , 2025 , 313 : 122764 .

LIU Hua , CHEN Danyang , YANG Xinhui , et al . Intestine-targeted controlled hydrogen-releasing MgH 2 microcapsules for improving the mitochondrial metabolism of inflammatory bowel disease [J ] . Advanced Functional Materials , 2024 , 34 ( 33 ): 2316227 .

LIU Boyan , LV Peixun , ZHANG Xiaoyi , et al . Zn-Fe primary battery-enabled controlled hydrogen release in stomach for improving insulin resistance in obesity-associated type 2 diabetes [J ] . Bioactive Materials , 2024 , 33 : 242 - 250 .

MLINAR B , MARC J , JANEZ A , et al . Molecular mechanisms of insulin resistance and associated diseases [J ] . Clinica Chimica Acta , 2007 , 375 ( 1/2 ): 20 - 35 .

GOYAL R K , GUO Yanmei , MASHIMO H . Advances in the physiology of gastric emptying [J ] . Neurogastroenterology & Motility , 2019 , 31 ( 4 ): e13546 .

SCHWARZ R , KASPAR A , SEELIG J , et al . Gastrointestinal transit times in mice and humans measured with 27 Al and 19 F nuclear magnetic resonance [J ] . Magnetic Resonance in Medicine , 2002 , 48 ( 2 ): 255 - 261 .

WAN Weilin , LIN Y J , CHEN H L , et al . In situ nanoreactor for photosynthesizing H 2 gas to mitigate oxidative stress in tissue inflammation [J ] . Journal of the American Chemical Society , 2017 , 139 ( 37 ): 12923 - 12926 .

ZHANG Boyu , WANG Fei , ZHOU Hua , et al . Polymer dots compartmentalized in liposomes as a photocatalyst for in situ hydrogen therapy [J ] . Angewandte Chemie International Edition , 2019 , 58 ( 9 ): 2744 - 2748 .

MURA S , NICOLAS J , COUVREUR P . Stimuli-responsive nanocarriers for drug delivery [J ] . Nature Materials , 2013 , 12 ( 11 ): 991 - 1003 .

ZHAO Bin , WANG Yingshuai , YAO Xianxian , et al . Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst [J ] . Nature Communications , 2021 , 12 ( 1 ): 1345 .

XU Yangsen , FAN Mingjian , YANG Wenjuan , et al . Homogeneous carbon/potassium-incorporation strategy for synthesizing red polymeric carbon nitride capable of near-infrared photocatalytic H 2 production [J ] . Advanced Materials , 2021 , 33 ( 39 ): 2101455 .

YANG Bowen , CHEN Yu , SHI Jianlin . Mesoporous silica/organosilica nanoparticles: synthesis, biological effect and biomedical application [J ] . Materials Science and Engineering: R Reports , 2019 , 137 : 66 - 105 .

YOU Yanling , ZHU Yaxuan , JIANG Junjie , et al . Water-enabled H 2 generation from hydrogenated silicon nanosheets for efficient anti-inflammation [J ] . Journal of the American Chemical Society , 2022 , 144 ( 31 ): 14195 - 14206 .

CHEN Huanhuan , GUO Yunfei , ZHANG Zhewei , et al . Symbiotic algae-bacteria dressing for producing hydrogen to accelerate diabetic wound healing [J ] . Nano Letters , 2022 , 22 ( 1 ): 229 - 237 .

CAMMACK R . Hydrogenase sophistication [J ] . Nature , 1999 , 397 ( 6716 ): 214 - 215 .

SUN Rui , LIU Xiaocen , LI Guangzhi , et al . Photoactivated H 2 nanogenerator for enhanced chemotherapy of bladder cancer [J ] . ACS Nano , 2020 , 14 ( 7 ): 8135 - 8148 .

YAO Xianxian , CHEN Danyang , ZHAO Bin , et al . Acid-degradable hydrogen-generating metal-organic framework for overcoming cancer resistance/metastasis and off-target side effects [J ] . Advanced Science , 2022 , 9 ( 10 ): 2101965 .

GONG Fei , XU Jiachen , LIU Bo , et al . Nanoscale CaH 2 materials for synergistic hydrogen-immune cancer therapy [J ] . Chem , 2022 , 8 ( 1 ): 268 - 286 .

CHEN Jiajie , LIN Shiyang , ZHAO Doudou , et al . Palladium nanocrystals-engineered metal-organic frameworks for enhanced tumor inhibition by synergistic hydrogen/photodynamic therapy [J ] . Advanced Functional Materials , 2021 , 31 ( 4 ): 2006853 .

DENG Ronghui , ZOU Meizhen , ZHENG Diwei , et al . Nanoparticles from cuttlefish ink inhibit tumor growth by synergizing immunotherapy and photothermal therapy [J ] . ACS Nano , 2019 , 13 ( 8 ): 8618 - 8629 .

YUAN Guanglong , CEN Jieqiong , LIAO Jiamin , et al . In situ hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies [J ] . Nanoscale , 2021 , 13 ( 37 ): 15576 - 15589 .

WANG Shibo , LIU Xinhua , LI Bin , et al . Bacteria-assisted selective photothermal therapy for precise tumor inhibition [J ] . Advanced Functional Materials , 2019 , 29 ( 35 ): 1904093 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Diffusion Characteristics and Influencing Factors in Case of Hydrogen Leakage from Fuel Cell Vehicles Running in Tunnels

Energy Efficiency Optimization of the Cryogenic Air Separation Process for Electronic-Grade Ultra Pure Nitrogen

Electrothermal Coupling Research on the Evolutionary Law of Anti-Corona Performance for High-Altitude Air-Cooled Generators

Bi-Level Multi-Obj ective Optimization of a Wind-Solar Coupled Hydrogen Production System Based on the Synergy of Hybrid Electrolyzer Arrays

Integrated and Joint Design Optimization of Centrifugal Compressor Impeller and Casing Treatment at Multiple Working Points

Related Author

No data

Related Institution

No data

⁰