Kinetic Analysis on Causality of Triple Network in AD Patients

MAO Bi; LI Youjun; YAO Nan; LI Chenxi; HUANG Zigang

doi:10.7652/xjtuxb202208018

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Kinetic Analysis on Causality of Triple Network in AD Patients

更新时间：2025-07-09

- Kinetic Analysis on Causality of Triple Network in AD Patients
- Vol. 56, Issue 8, Pages: 168-177(2022)
- 作者机构：
  
  1. 西安交通大学生物医学信息工程教育部重点实验室,西安,710049
  2. 西安交通大学类脑智能研究中心,西安,710049
  3. 西安理工大学理学院,西安,710048
  4. 空军军医大学军事医学心理学系,西安,710032
- 作者简介：
- 基金信息：
- DOI：10.7652/xjtuxb202208018
  CLC： R318
- Online First：10 August 2022，
  
  Published：2022
- 稿件说明：
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MAO Bi, LI Youjun, YAO Nan, et al. Kinetic Analysis on Causality of Triple Network in AD Patients[J]. 2022, 56(8): 168-177.
DOI：

MAO Bi, LI Youjun, YAO Nan, et al. Kinetic Analysis on Causality of Triple Network in AD Patients[J]. 2022, 56(8): 168-177. DOI： 10.7652/xjtuxb202208018.

摘要

为深入探究阿尔茨海默症(Alzheimer's disease

AD)对患者大脑功能网络之间因果性连接的具体损伤情况

采用非线性的因果性分析方法——收敛交叉映射方法

区别于传统的基于线性模型的脑网络分析方法

研究在静息状态下阿尔茨海默症对默认模式网络(DMN)、中央执行网络(CEN)和显著网络(SN)中各个脑区之间因果性连接的影响

以及这种变化与临床认知水平指标之间的关联性。研究结果显示

静息状态下阿尔茨海默症患者的DMN、CEN和SN网络脑区之间的因果性连接普遍降低

而DMN和CEN网络中的因果性连接变化与认知行为相关性较强。本文研究从动力学角度探索了阿尔茨海默症对大脑3个重要功能网络因果性连接的损伤情况

可为深入理解静息态下AD大脑内在的动力学变化特征提供帮助。

Abstract

This study focuses on exploring the specific damage of causal connections between brain functional networks in patients with Alzheimer's disease(AD). A nonlinear causality analysis method

namely convergent cross mapping

which is different from the brain network analysis method based on the conventional linear model

is used to study the effects of Alzheimer's disease on the causal connections between brain regions in the default mode network(DMN)

central executive network(CEN)and salience network(SN)in the resting state

as well as the association between such effects and clinical indicators. The results show that the causal connections between brain regions in DMN

CEN and SN networks generally decreased in patients with Alzheimer's disease

and the altered causal connections in DMN and CEN networks were strongly correlated with subjects' cognitive level. This study examines the damage of the causal connections between three important functional networks of the brain caused by Alzheimer's disease from the perspective of kinetics

which is helpful for the in-depth understanding of the dynamic characteristics of the AD brain in the resting state.

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references

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