Influence of Mixture Composition on Cooling Rate of a Freeze-Dryer with an Auto-Cascade Refrigerating System

您当前的位置：

首页 >

文章列表页 >

Influence of Mixture Composition on Cooling Rate of a Freeze-Dryer with an Auto-Cascade Refrigerating System

更新时间：2025-07-09

- Influence of Mixture Composition on Cooling Rate of a Freeze-Dryer with an Auto-Cascade Refrigerating System
- Vol. 43, Issue 11, Pages: 37-42(2009)
- 作者机构：
  
  浙江大学制冷与低温研究所,杭州,310027
- 作者简介：
- 基金信息：
- DOI：
  CLC： TB64
- Online First：10 November 2009，
  
  Published：2009
- 稿件说明：
移动端阅览
Influence of Mixture Composition on Cooling Rate of a Freeze-Dryer with an Auto-Cascade Refrigerating System[J]. 2009, 43(11): 37-42.
DOI：

Influence of Mixture Composition on Cooling Rate of a Freeze-Dryer with an Auto-Cascade Refrigerating System[J]. 2009, 43(11): 37-42. DOI：

摘要

首次对以精馏型自复叠制冷系统为冷源的冷冻干燥装置降温过程进行了准稳态数值模拟

发现在混合工质成分和循环压比给定时

循环单位容积制冷量随压力位变化有峰值存在

具有与纯工质循环不同的特征.通过定成分和变成分下循环制冷量的优化

深入分析了混合工质成分对降温过程中各温度位循环制冷量的影响规律

从而可以为各种不同降温速率要求的冻结工艺设计混合工质的成分

为冻结工艺所要求的降温速率控制提供便利.借助于总单位温降时间和单位温降时间两个新概念

对物品热容量与搁板蒸发器热容量相比很小时的特例进行了深入分析.设计和制作了一台以精馏型自复叠制冷系统为冷源的冷冻干燥装置

实现了-60～-80 ℃温区的稳定运行

实验结果初步验证了理论分析所得到的结论.

Abstract

A quasi-steady state simulation was conducted on the cooling process of a freeze-dryer with an auto-cascade refrigerating system using a rectification column. It is found that

unlike the system with a pure refrigerant

a peak value of the volumetric refrigerating capacity occurs as the cycle pressure level varies at a specified mixture composition and a pressure ratio. Optimization of the cycle refrigerating capacity was also performed at the different mixture compositions and the influence of the mixture composition on the cycle refrigerating capacity at different temperature levels in the cooling process was analyzed. The two new concepts

total unit cooling time and unit cooling time

were applied for the detailed analysis on a special case in which the heat capacity of a freeze-drying sample was much smaller than that of the shelf evaporator. An experimental freeze-dryer with an auto-cascade refrigerating system using a rectification column was designed and it operated steadily from -60 ℃ to -80 ℃. The simulation results are in consistency with the experimental data.

关键词

Keywords

references

PODBIELNIAK W J. Art of refrigeration: USA, 2041725 [P]. 1936-05-26.

KLEEMENKO A P. One-flow cascade cycle[C]∥Proceedings 10th International Congress of Refrigeration. Copenhagen, Denmark: Pergamon Press, 1959: 34-39.

MISSIMER D J. Control system for low temperature refrigeration: USA, 3698202 [P]. 1972-10-17.

MISSIMER D J. Self-balancing low temperature refrigeration system: USA, 3768275 [P]. 1973-10-30.

LITTLE W A. Self-cleaning low temperature refrigeration system: USA, 5617739 [P]. 1997-04-08.

LITTLE W A, SAPOZHNIKOV I. Self-cleaning cryogenic refrigeration system: USA, 5724832 [P]. 1998-03-10.

陈光明,张绍志,王剑锋,等. 低温制冷机: 中国, 99203770.0 [P]. 2000-01-01.

陈光明,张绍志,王勤. 深度制冷装置: 中国, 02110664.9 [P]. 2002-08-14.

王勤, 陈光明. 有限大低温热源混合工质节流制冷循环特性分析 [J]. 工程热物理学报, 2003, 24(2): 181-185.

WANG Qin, CHEN Guangming. The analyses of characteristics of J-T refrigeration cycles using mixed refrigerants with finite low temperature heat reservoir [J]. Journal of Engineering Thermophysics, 2003, 24(2): 181-185.

王勤, 陈光明. 多元混合工质精馏循环的优化计算与实验研究 [J]. 低温工程, 2003, 133(3): 42-47.

WANG Qin, CHEN Guangming. Optimization calculation and experimental study on multi-component rectification cycles using mixed refrigerants [J].Cryogenics, 2003, 133(3): 42-47.

曹丹,王勤,陈光明.一种新型的自动复叠制冷循环 [J]. 低温工程, 2003, 135(5): 49-55.

CAO Dan, WANG Qin, CHEN Guangming. A new auto-cascade refrigerating cycle [J].Cryogenics, 2003, 133(3): 42-47.

WANG Q, ZHANG H F, CHEN G M. A thermodynamic optimization of counterflow recuperative-type heat exchangers [C/CD]∥Proceedings of the Twentieth International Cryogenic Engineering Conference. Beijing,China: Beijing World Publishing Corporation, 2004:file 13N18.

张爱民,陈光明,王勤. 一种小型天然气液化装置的实验研究 [J]. 浙江大学学报(工学版), 2008, 42(11): 1973-1976.

ZHANG Aimin, CHEN Guangming, WANG Qin. Experimental study on a small-scale liquefied natural gas apparatus [J]. Journal of Zhejiang University(Engineering Science), 2008, 42(11): 1973-1976.

WU J F, GONG M Q, LIU J L, et al. A new type mixture refrigeration auto-cascade cycle with partial condensation and separation reflux exchanger and its preliminary experimental test [J]. Adv Cryog Engrg, 2002, 45: 887-892.

GONG M Q, WU J F, LUO E G. Performances of the mixed-gases Joule-Thomson refrigeration cycles for cooling fixed-temperature heat loads [J]. Cryogenics, 2004, 44(12): 847-857.

WANG W. Lyophilization and development of solid protein pharmaceuticals [J]. Int J Pharm, 2000, 203: 1-60.

LEMMON E W, HUBER M L, McLINDER M O. NIST reference fluid thermodynamic and transport properties database-REFPROP, Version 7.0 [DB]. Maryland, USA: National Institute of Standards and Technology, 2002.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Online Measurement Method for Components of Auto-Cascade Refrigeration System

A Multi-Member Artificial Bee Colony Algorithm for Constrained Optimization Problems

Optimization for Ultra-High Voltage AC Bushing Screening Electrode Structure

Optimization of Compressors Displacement Ratio in R134a/R23 Cascade Refrigeration System

Optimization for Low-Pressure Multi-Stage Turbine Considering Influences of Aerodynamic Losses and Wetness Losses

Related Author

YAN Gang

LIU Guoqiang

JING Dongliang

LI Yinlong

郑建国 1

王翔 1

张施令

Related Institution

School of Energy and Power Engineering, Xi'an Jiaotong University

Glorious Sun School of Business and Management, Donghua University

School of Civil Engineering, Zhengzhou Institute of Aeronautical Industry Management

State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University

School of Energy and Power Engineering, Xi'an Jiatotong University

⁰