Preparation and Biocompatibility Evaluation of Modified Hydroxyapatite/Poly L-Lactic Acid Composites

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Preparation and Biocompatibility Evaluation of Modified Hydroxyapatite/Poly L-Lactic Acid Composites

更新时间：2025-07-09

- Preparation and Biocompatibility Evaluation of Modified Hydroxyapatite/Poly L-Lactic Acid Composites
- Vol. 44, Issue 12, Pages: 114-118(2010)
- 作者机构：
  
  哈尔滨商业大学食品工程学院,哈尔滨,150076
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q813.1
- Online First：10 December 2010，
  
  Published：2010
- 稿件说明：
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Preparation and Biocompatibility Evaluation of Modified Hydroxyapatite/Poly L-Lactic Acid Composites[J]. 2010, 44(12): 114-118.
DOI：

Preparation and Biocompatibility Evaluation of Modified Hydroxyapatite/Poly L-Lactic Acid Composites[J]. 2010, 44(12): 114-118. DOI：

摘要

针对聚乳酸(PLLA)和羟基磷灰石(HA)两者复合时界面相容性差的问题

采用硅烷偶联剂十八烷基三氯硅烷(OTS)对HA颗粒进行了表面改性

通过热诱导相分离法制备了OTS-HA/PLLA多孔复合材料.扫描电镜结果表明

OTS-HA/PLLA多孔复合材料中改性HA颗粒的分布较均匀

PLLA和改性HA颗粒之间的界面相容性得到了改善.孔隙率测试表明

OTS-HA/PLLA多孔复合材料的孔隙率均大于90%

适合骨修复材料对孔隙率的要求.细胞培养结果表明

复合材料对骨髓间充质干细胞的生长无抑制作用

细胞在材料表面能正常黏附、生长、增殖

具有良好的细胞附着形态和细胞增殖率

表现出了良好的生物相容性.

Abstract

In order to improve the interface compatibility between poly L-lactic acid(PLLA)and Hydroxyapatite(HA)

octadecyltrichlorosilane(OTS)is used as a coupling agent to modify the surface of HA by a silanization reaction

and corresponding OTS-HA/PLLA porous composites are prepared by thermally induced phase separation method. Results from scanning electron microscopy show that OTS modification improves both the distribution of HA particles

and the interface compatibility between HA and PLLA. The porosities of OTS-HA/PLLA porous composite are greater than 90%

which well meets the requirement of bone regeneration materials. Also

results of in vitro cells cultivation show no negative effects on the growth of BMSCs(bone mesenchymal stem cells). The cells can well adhere and grow on the surface

and excellent cell spreading and proliferation are observed. The OTS-HA/PLLA porous composites show good biocompatibility.

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references

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